BACKGROUND The mortality rate during the acute myocardial infarction (AMI) phase has substantially decreased, but post-AMI cardiac remodeling remains an important factor affecting patient prognosis. Several circulating long noncoding RNAs (lncRNAs) are reportedly involved in the chronic pathological process of cardiac function and remodeling in cardiovascular diseases. However, the potential roles of these circulating lncRNAs as biomarkers of cardiac function and remodeling during early-stage AMI remain unclear. METHODS Fifty-three patients with AMI and 90 controls without AMI were consecutively enrolled in this study. Clinical parameters and blood samples at different time points (i.e., 24 h and 3 days) were collected. RESULTS Compared with the controls, the circulating levels of cardiac hypertrophy-associated transcript (CHAST) significantly increased in AMI patients, and the CHAST levels obviously decreased at 3 days. In AMI patients, the expression levels of CHAST at 24 h were positively associated with cardiac contractile function and measured as left ventricular ejection fraction and left ventricular short-axis shortening rate (all P < 0.050). Multivariate regression analysis indicated that the expression level of CHAST at 24 h was an independent predictor of cardiac contractile function (standardized β = 0.319, P =0.034). When grouped according to the quartile values of the CHAST in the AMI population, patients with the highest quartiles of CHAST expression level showed better cardiac contractile function than all the other quartiles (all P < 0.050). CONCLUSION CHAST was an independent predictor of cardiac contractile function at early-stage AMI and may serve as a candidate biomarker for cardiac remodeling.

中文翻译：

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急性心肌梗死患者早期表达的循环长非编码RNA CHAST与心脏收缩功能有关。

背景技术急性心肌梗塞（AMI）阶段的死亡率已大大降低，但是AMI后心脏重塑仍然是影响患者预后的重要因素。据报道，几种循环的长非编码RNA（lncRNA）参与了心脏功能的慢性病理过程和心血管疾病的重塑。然而，这些循环的lncRNA作为早期AMI期间心脏功能和重塑的生物标志物的潜在作用仍不清楚。方法连续纳入53例AMI患者和90例无AMI的对照组。收集不同时间点（即24小时和3天）的临床参数和血液样本。结果与对照相比，AMI患者的心脏肥大相关转录本（CHAST）的循环水平显着升高，而CHAST水平在3天时明显降低。在AMI患者中，CHAST在24小时的表达水平与心脏收缩功能呈正相关，并以左心室射血分数和左心室短轴缩短率来衡量（所有P <0.050）。多元回归分析表明，CHAST在24 h的表达水平是心脏收缩功能的独立预测因子（标准β= 0.319，P = 0.034）。根据AMI人群中CHAST的四分位数进行分组时，CHAST表达水平四分位数最高的患者显示出比所有其他四分位数更好的心脏收缩功能（所有P <0.050）。