Many cancers occur from locations of inflammation due to chronic irritation and/or infection. Tumor microenvironment contains various different inflammatory cells and mediators that orchestrate diverse neoplastic processes, including proliferation, survival, adhesion and migration. In parallel, tumor cells have adapted some of the signaling molecules used by inflammatory cells, such as selectins and chemokines as well as their receptors for invasion, extravasation and subsequently metastasis. Expression and/or activation of the majority of these molecules is mediated by the proprotein convertases (PCs); proteases expressed by both tumor cells and inflammatory cells. This review analyzes the potential role of these enzymatic system in inflammation-associated cancer impacting on the malignant and metastatic potential of cancer cells, describing the possible use of PCs as a new anti-inflammatory therapeutic approach to tumor progression and metastasis.

中文翻译：

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前蛋白转化酶：炎症相关恶性肿瘤和转移的关键因素。

由于慢性刺激和/或感染，许多癌症都发生在炎症部位。肿瘤微环境包含各种不同的炎症细胞和介体，可以协调各种肿瘤过程，包括增殖，存活，粘附和迁移。同时，肿瘤细胞已经适应了炎症细胞使用的某些信号分子，例如选择素和趋化因子，以及它们的受体，用于侵袭，外渗和随后的转移。这些分子中的大多数的表达和/或激活是由原蛋白转化酶（PCs）介导的。肿瘤细胞和炎性细胞表达的蛋白酶。这篇综述分析了这些酶系统在炎症相关癌症中对癌细胞的恶性和转移潜能的潜在作用，