Supplemental Digital Content is available in the text. Increased blood pressure (BP) variability (BPV) is an independent risk factor of cardiovascular events among hypertensive patients. The arterial baroreceptor reflex is a powerful regulator of BP and attenuates BPV via a sympathetic negative feedback control. Conventional baroreceptor activation therapy (cBAT) electrically stimulates the carotid baroreceptors with constant stimulation parameters. While cBAT lowers BP, it does not mount a pressure feedback mechanism. We hypothesized that baroreceptor activation therapy with a pressure feedback system (smart BAT [sBAT]) is able to reduce BPV as well as lower BP. We developed sBAT that electrically stimulated baroreceptors at a frequency proportional to the difference between instantaneous BP and a preset reference pressure, and compared its performance with cBAT. In 14-week-old spontaneously hypertensive rats (n=6), we implanted BP telemeter and created impaired arterial baroreceptors by modified sino-aortic denervation. One week after surgical preparation, we administered sBAT, cBAT or no stimulation (sham) for 15 minutes and compared BP and BPV under freely moving condition. Both cBAT and sBAT significantly lowered mean BP (sham, 141.3±12.8; cBAT, 114.3±11.4; and sBAT, 112.0±7.3 mm Hg). Conventional BAT did not affect BPV at all, while sBAT significantly reduced BPV (sham, 15.4±2.6; cBAT, 16.0±5.2; and sBAT, 9.7±3.3 mm Hg). sBAT also prevented transient excessive BP rise and fall. In conclusion, sBAT was capable of reducing BP and attenuating BPV in hypertensive rats with impaired baroreceptor. sBAT is a novel treatment option for hypertensive patients with increased BPV.

中文翻译：

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智能压力感受器激活疗法显着降低压力感受器受损高血压大鼠的血压变异性

补充数字内容在文本中可用。血压（BP）变异性（BPV）增加是高血压患者心血管事件的独立危险因素。动脉压力感受器反射是 BP 的强大调节器，并通过交感神经负反馈控制减弱 BPV。传统的压力感受器激活疗法 (cBAT) 以恒定的刺激参数电刺激颈动脉压力感受器。虽然 cBAT 降低了血压，但它没有安装压力反馈机制。我们假设使用压力反馈系统（智能 BAT [sBAT]）的压力感受器激活疗法能够降低 BPV 以及降低血压。我们开发了 sBAT，它以与瞬时血压和预设参考压力之间的差异成正比的频率电刺激压力感受器，并将其性能与 cBAT 进行比较。在 14 周大的自发性高血压大鼠 (n = 6) 中，我们植入了 BP 遥测仪，并通过改良的窦主动脉去神经术产生受损的动脉压力感受器。手术准备一周后，我们给予 sBAT、cBAT 或无刺激（假手术）15 分钟，并在自由移动条件下比较 BP 和 BPV。cBAT 和 sBAT 均显着降低了平均血压（假手术，141.3±12.8；cBAT，114.3±11.4；和 sBAT，112.0±7.3 mm Hg）。传统 BAT 根本不影响 BPV，而 sBAT 显着降低 BPV（假手术，15.4±2.6；cBAT，16.0±5.2；和 sBAT，9.7±3.3 mm Hg）。sBAT 还可以防止瞬时过度的血压上升和下降。总之，sBAT能够降低压力感受器受损的高血压大鼠的血压并减弱BPV。