Primary immunodeficiency Disorders (PIDD) are a varied group of heritable disorders characterized by defects in components of the innate and/or adaptive arms of the immune system. Although diagnosing these disorders is often challenging, the skin is a readily accessible and easily assessable organ that may provide clues to a diagnosis of PIDD. Specifically, many immunodeficiencies are associated with characteristic cutaneous eruptions that, based on their morphology, distribution and symptomatology, may suggest a specific underlying diagnosis. This review will discuss an approach to identifying and managing PIDDs that typically present with eczematous dermatitis.

中文翻译：

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湿疹性皮炎在原发性免疫缺陷中的作用：皮肤诊断线索的综述。

原发性免疫缺陷疾病（PIDD）是一类可遗传的疾病，其特征是免疫系统先天和/或适应性臂的组成部分存在缺陷。尽管诊断这些疾病通常具有挑战性，但皮肤是易于接近且易于评估的器官，可能为诊断PIDD提供线索。具体而言，许多免疫缺陷症与特征性皮肤爆发有关，基于它们的形态，分布和症状，可能提示特定的潜在诊断。这篇综述将讨论一种识别和管理典型的湿疹性皮炎的PIDD的方法。