Acid‐Catalyzed Pseudo Five‐Component Annulation for a General One‐Pot Synthesis of 2,4,6‐Triaryl Pyrimidines,Asian Journal of Organic Chemistry

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Acid‐Catalyzed Pseudo Five‐Component Annulation for a General One‐Pot Synthesis of 2,4,6‐Triaryl Pyrimidines
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-01-17 , DOI: 10.1002/ajoc.201900700
Yuxin Ding _{1,

2} , Renchao Ma ₁ , Robert C. Hider ₃ , Yongmin Ma _{1,

2}

Affiliation

A facile and general synthesis of 2,4,6‐triaryl pyrimidines has been developed. It involves a one‐pot [2+1+1+1+1] pseudo five‐component annulation of one methyl ketone, two aldehydes and two NH₄OAc catalyzed by TfOH. One C−C and four C−N bonds are formed during the oxidative annulation process. The reaction shows good tolerance of many important functional groups in air and produces only water as the coproduct, making this methodology a highly versatile alternative to the existing methods for structuring pyrimidine framework.

中文翻译：

酸催化的伪五组分环化反应，用于一锅合成2,4,6-三芳基嘧啶

已经开发了一种简便且通用的2,4,6-三芳基嘧啶合成方法。它涉及由TfOH催化的一种甲基酮，两种醛和两种NH ₄ OAc的单锅[2 + 1 + 1 + 1 + 1]假五组分环化反应。在氧化环化过程中形成一个C-C键和四个C-N键。该反应显示出对空气中许多重要官能团的良好耐受性，并且仅产生水作为副产物，从而使该方法成为用于构建嘧啶骨架的现有方法的高度通用的替代方法。

更新日期：2020-01-17

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