Assembly of Water‐Soluble Sugar‐Coated AIE‐Active Fluorescent Organic Nanoparticles for the Detection of Ginsenosides Based on Carbohydrate‐Carbohydrate Interactions,ChemNanoMat

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Assembly of Water‐Soluble Sugar‐Coated AIE‐Active Fluorescent Organic Nanoparticles for the Detection of Ginsenosides Based on Carbohydrate‐Carbohydrate Interactions
ChemNanoMat ( IF 2.6 ) Pub Date : 2020-01-22 , DOI: 10.1002/cnma.201900695
Li‐yan Jia ₁ , Guang‐jian Liu ₁ , Yan‐ming Ji ₁ , Yuan Zhang ₁ , Guo‐wen Xing ₁

Affiliation

A series of water‐soluble turn–on fluorescent organic nanoparticles (FONs) were designed and assembled for the detection of ginsenosides based on carbohydrate‐carbohydrate interactions (CCIs) and aggregation‐induced emission mechanism. Especially, the tetraphenylethylene luminogen coated by four sialic acids (TPE4S) exhibited a considerably high fluorescence enhancement (32‐fold) upon addition of polyglycosylated protopanaxadiol (PPD) derivatives. It is the first time that CCIs were employed for probing amphiphilic ginsenosides effectively. Our current results provide a novel sensing strategy using water‐soluble FONs to detect widely existing saponins with important biological activities.

中文翻译：

水溶性糖衣AIE-活性荧光有机纳米粒子的组装，用于基于糖-碳水化合物相互作用的人参皂苷检测

设计并组装了一系列水溶性的开启式荧光有机纳米粒子（FON），用于基于碳水化合物与碳水化合物的相互作用（CCI）和聚集诱导的发射机理检测人参皂甙。尤其是，当添加了聚糖基化的原托氧大麻酚（PPD）衍生物时，被四种唾液酸（TPE4S）包覆的四苯基乙烯发光剂显示出相当高的荧光增强作用（32倍）。这是首次将CCI用于有效地探测两亲人参皂苷。我们当前的结果提供了一种使用水溶性FON来检测广泛存在的具有重要生物活性的皂苷的新型传感策略。

更新日期：2020-01-22

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