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Stepwise Construction of Disulfides in Peptides.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-02-20 , DOI: 10.1002/cbic.201900717 Rongjun He 1 , Jia Pan 2 , John P Mayer 3 , Fa Liu 4
ChemBioChem ( IF 2.6 ) Pub Date : 2020-02-20 , DOI: 10.1002/cbic.201900717 Rongjun He 1 , Jia Pan 2 , John P Mayer 3 , Fa Liu 4
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The disulfide bond plays an important role in biological systems. It defines global conformation, and ultimately the biological activity and stability of the peptide or protein. It is frequently present, singly or multiply, in biologically important peptide hormones and toxins. Numerous disulfide-containing peptides have been approved by the regulatory agencies as marketed drugs. Chemical synthesis is one of the prerequisite tools needed to gain deep insights into the structure-function relationships of these biomolecules. Along with the development of solid-phase peptide synthesis, a number of methods of disulfide construction have been established. This minireview will focus on the regiospecific, stepwise construction of multiple disulfides used in the chemical synthesis of peptides. We intend for this article to serve a reference for peptide chemists conducting complex peptide syntheses and also hope to stimulate the future development of disulfide methodologies.
中文翻译：
肽中二硫键的逐步构建。
二硫键在生物系统中起重要作用。它定义了整体构象，并最终定义了肽或蛋白质的生物学活性和稳定性。它在生物学上重要的肽激素和毒素中经常单独或多次存在。许多含二硫键的肽已被监管机构批准为市售药物。化学合成是深入了解这些生物分子的结构-功能关系所需的先决条件工具之一。随着固相肽合成的发展，已经建立了许多二硫键构建方法。本篇综述将集中于在肽的化学合成中使用的多种二硫键的区域特异性，逐步构建。
更新日期：2020-02-20
中文翻译：
肽中二硫键的逐步构建。
二硫键在生物系统中起重要作用。它定义了整体构象，并最终定义了肽或蛋白质的生物学活性和稳定性。它在生物学上重要的肽激素和毒素中经常单独或多次存在。许多含二硫键的肽已被监管机构批准为市售药物。化学合成是深入了解这些生物分子的结构-功能关系所需的先决条件工具之一。随着固相肽合成的发展，已经建立了许多二硫键构建方法。本篇综述将集中于在肽的化学合成中使用的多种二硫键的区域特异性，逐步构建。
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