Facile synthesis of novel heterocyclic compounds based on pyridine moiety with pharmaceutical activities,Journal of Heterocyclic Chemistry

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Facile synthesis of novel heterocyclic compounds based on pyridine moiety with pharmaceutical activities
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2019-12-29 , DOI: 10.1002/jhet.3881
Naglaa F. H. Mahmoud ₁ , Ahmed El‐Sewedy ₁

Affiliation

A novel run of fused heterocyclic derivatives containing pyridine moieties has been disclosed by allowing 2‐amino‐4‐phenyl‐6‐(phenyl amino)pyridine‐3,5‐dicarbonitrile 1 to undergo annulation reactions with different reagents. Most of synthesized compounds have moderate to strong antitumor activity against HePG‐2 and MCF‐7. Moreover, MOE 2014.09 software was used to run the computational studies to support the biological activity results. The assigned structures for all the newly prepared derivatives were ascertained on the basis of elemental analyses and spectral data.

中文翻译：

基于吡啶部分的具有药物活性的新型杂环化合物的合成

一种新颖的含吡啶基部分稠合杂环衍生物的运行已通过使2-氨基-4-苯基-6-（苯基氨基）吡啶-3,5-二甲腈公开1接受用不同的试剂环化反应。大多数合成的化合物对HePG-2和MCF-7具有中等至强烈的抗肿瘤活性。此外，MOE 2014.09软件用于运行计算研究以支持生物活性结果。根据元素分析和光谱数据确定所有新制备的衍生物的指定结构。

更新日期：2019-12-30

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