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Metal complexes for mitochondrial bioimaging.
Journal of Inorganic Biochemistry ( IF 3.8 ) Pub Date : 2019-12-30 , DOI: 10.1016/j.jinorgbio.2019.110985
Ruilin Guan 1 , Lina Xie 1 , Thomas W Rees 1 , Liangnian Ji 1 , Hui Chao 1
Affiliation  

Mitochondria are essential organelles in eukaryotic cells, containing various signaling molecules and important enzymes associated with cell growth, death, and proliferation. The visualization of mitochondria and their biochemistry with confocal microscopy, fluorescence (phosphorescence) lifetime microscopy (FLIM, PLIM), and super-resolution microscopy has therefore been of great interest in recent years. In particular, transition metal complexes have emerged as excellent mitochondria-targeting probes, due to their high photostabilities, large Stokes shifts, tunable chemical structures and long luminescence lifetimes. In this review, we focus on platinum, ruthenium and iridium complexes, and their application as detectors of micro-environmental alterations as well as for the imaging of signaling molecules inside mitochondria.

中文翻译:

线粒体生物成像的金属配合物。

线粒体是真核细胞中必不可少的细胞器,包含各种信号分子和与细胞生长,死亡和增殖相关的重要酶。因此,近年来,共聚焦显微镜,荧光(磷光)寿命显微镜(FLIM,PLIM)和超分辨率显微镜对线粒体及其生物化学的可视化引起了人们的极大兴趣。特别地,由于过渡金属络合物的高光稳定性,大的斯托克斯位移,可调节的化学结构和长的发光寿命,它们已成为出色的线粒体靶向探针。在这篇综述中,我们重点研究铂,钌和铱配合物及其在微环境变化检测器以及线粒体内信号分子成像中的应用。
更新日期:2019-12-30
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