BACKGROUND Considering the crucial role of low-density lipoprotein-cholesterol (LDL-C) concentration in determining cardiovascular risk, the accuracy of LDL-C estimation is essential. To date, various types of formulae have been introduced, albeit their accuracy has not been assessed in varied populations. In this study, the accuracy of eight formulae for LDL-C estimation was evaluated in an Iranian population. METHODS A data set of 2752 individuals was included in the study and all samples were analyzed in term of lipid profiles using direct homogeneous assay. The population was divided into various subgroups based on the triglyceride (TG), high-density lipoprotein- cholesterol (HDL-C), total cholesterol (TC), fasting blood sugar (FBS) and age values and estimated LDL-C values by Friedewald, Chen, de Cordova, Vujovic, Anandaraja, Hattori, Ahmadi, and Puavillai equations were compared to the directly measured LDL-C in each subgroup. RESULTS Estimated LDL-C values by Puavillai formulae showed an insignificant difference compared to the directly measured LDL-C in subjects with high level of TG. However, for TG range < 3.38 mmol/L and high levels of HDL-C, the difference between the means of estimated LDL-C by Hattori and de Cordova formulas, and directly measured LDL-C was relatively lower than other equations. In addition, estimated LDL-C by Hattori and de Cordova formulae had insignificant differences as compared to the direct LDL-C at some levels of cholesterol, the normal level of FBS and some age ranges. CONCLUSIONS Therefore, it seems that Hattori and de Cordova formulas can be considered as the best alternatives for LDL-C direct measurement in the Iranian population, especially for healthy subjects.

中文翻译：

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在具有不同代谢健康状况的伊朗受试者中评估八种LDL-C估算公式。

背景技术考虑到低密度脂蛋白胆固醇（LDL-C）浓度在确定心血管风险中的关键作用，LDL-C估计的准确性至关重要。迄今为止，已经引入了各种类型的公式，尽管尚未在各种人群中评估其准确性。在这项研究中，在伊朗人口中评估了8个用于LDL-C估算的公式的准确性。方法本研究包括2752名个体的数据集，并使用直接均相测定法对所有样品的血脂谱进行了分析。根据甘油三酸酯（TG），高密度脂蛋白胆固醇（HDL-C），总胆固醇（TC），空腹血糖（FBS）和年龄值以及弗里德瓦尔德（Friedewald）估计的LDL-C值，将人群分为多个亚组。 ，陈，德科尔多瓦，武乔维奇，阿南达拉贾，服部丽，艾哈迈迪，和Puavillai方程与每个子组中直接测量的LDL-C进行了比较。结果在高TG受试者中，通过Puavillai公式估算的LDL-C值与直接测量的LDL-C相比，差异不显着。但是，对于TG范围<3.38 mmol / L和高水平的HDL-C，由Hattori和de Cordova公式估算的LDL-C的平均值与直接测量的LDL-C的平均值之间的差异要比其他公式要低。此外，在某些胆固醇水平，正常FBS水平和某些年龄范围内，由Hattori和de Cordova公式估算的LDL-C与直接LDL-C相比没有显着差异。结论因此，似乎可以将Hattori和de Cordova公式视为伊朗人口中LDL-C直接测量的最佳替代方法，