BACKGROUND COPD is a high prevalence chronic disease that involves large reductions of health-related quality of life (HRQL) of patients. This study aims to describe the HRQL of patients with COPD in Extremadura (Spain). METHODS This is a cross-sectional observational study carried out using a representative sample of patients diagnosed with COPD in Extremadura. The inclusion criteria were patients of legal age, diagnosed with COPD at least 12 months prior to the visit, residing in Extremadura, with electronic medical records available for the 12 months prior to the visit and providing informed consent. The intervention aimed to elicit HRQL indicators obtained from two validated questionnaires: EuroQol - 5 Dimensions - 5 Levels (EQ-5D-5L), and St. George's Respiratory Questionnaire-COPD (SGRQ-C). The main outcome measures were general HRQL (utility and visual analogue scale) and specific quality of life of COPD patients (total score and three component scores: Symptoms, Activity, and Impacts). Stepwise multiple regression analysis was applied to evaluate the association of EQ-5D-5L and SGRQ-C with respect to clinical and sociodemographic characteristics of the patients. RESULTS We recruited 386 patients (mean age 71.8 ± 10.3 years, 76.2% males). In the EQ-5D-5L, participants reported greater problems with respect to mobility (56.5%) and pain/discomfort (48.2%). The mean utility was 0.72 ± 0.31, and the SGRQ-C total score was 40.9 ± 25.0. The results of both questionnaires were associated with number of exacerbations in the last 12 months, level of COPD severity, gender, and education level of the patient (p < 0.05). CONCLUSIONS The results for both utility and total SGRQ-C score indicate that having suffered exacerbations in the last year, presenting a higher level of severity, being a woman, and having a low education level are related to worse HRQL in patients with COPD.

中文翻译：

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西班牙埃斯特雷马杜拉诊断患有慢性阻塞性肺病的患者的健康相关生活质量：一项观察性研究的结果。

背景技术COPD是一种高患病率的慢性疾病，其涉及患者健康相关生活质量（HRQL）的大幅下降。本研究旨在描述埃斯特雷马杜拉（西班牙）慢性阻塞性肺病患者的 HRQL。方法 这是一项横断面观察性研究，使用埃斯特雷马杜拉诊断患有慢性阻塞性肺病的患者的代表性样本进行。纳入标准是患者达到法定年龄，在就诊前至少 12 个月被诊断患有慢性阻塞性肺病，居住在埃斯特雷马杜拉，拥有就诊前 12 个月的电子病历并提供知情同意书。干预措施旨在引出从两份经过验证的问卷中获得的 HRQL 指标：EuroQol - 5 维度 - 5 个级别 (EQ-5D-5L) 和圣乔治呼吸问卷 - COPD (SGRQ-C)。主要结果指标是一般HRQL（效用和视觉模拟量表）和COPD患者的具体生活质量（总分和三个组成部分的分数：症状、活动和影响）。应用逐步多元回归分析来评估 EQ-5D-5L 和 SGRQ-C 与患者临床和社会人口学特征的关联。结果 我们招募了 386 名患者（平均年龄 71.8 ± 10.3 岁，76.2% 为男性）。在 EQ-5D-5L 中，参与者报告了更大的活动问题（56.5%）和疼痛/不适（48.2%）。平均效用为 0.72 ± 0.31，SGRQ-C 总分为 40.9 ± 25.0。两份问卷的结果均与过去 12 个月内病情加重次数、COPD 严重程度、性别和患者教育水平相关（p < 0.05）。结论 效用和 SGRQ-C 总分的结果表明，去年经历过病情加重、严重程度较高、女性以及受教育程度较低与 COPD 患者 HRQL 较差有关。