BACKGROUND The relationship between anti-estrogen drugs and macular telangiectasia type 2 (MacTel-2) remains unknown. Here we report a case with anti-estrogen maculopathy resembling MacTel-2 with improved visual function and macular morphology following cessation of anti-estrogen drugs. CASE PRESENTATION A 53-year-old woman presented with a 5-month history of central vision loss and anorthopia in both eyes. She had received oral tamoxifen followed by toremifene for 69 months. Funduscopy, fluorescein angiography, and optical coherence tomography (OCT) revealed MacTel-2-like findings OU. Fundus autofluorescence (FAF) showed hyper-autofluorescence at the fovea OU. Visual acuity, macular morphology on OCT, and FAF findings gradually improved after cessation of anti-estrogen drugs. CONCLUSIONS In the present case, visual acuity, macular morphology, and impairment of the retinal pigment epithelium (RPE) improved following cessation of anti-estrogen drugs, suggesting the relationship between retinal toxicity of anti-estrogen drugs and the development of MacTel-2-like findings. From these results and the previous observations, toxicity of both photoreceptor and RPE cells caused by anti-estrogen drugs may contribute to the development of anti-estrogen maculopathy similar to MacTel-2.

中文翻译：

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患有抗雌激素黄斑病（类似于黄斑性毛细血管扩张2型）的患者停止使用抗雌激素药物后视力和黄斑形态的改善：2致病假说。

背景技术抗雌激素药物与2型黄斑毛细血管扩张症（MacTel-2）之间的关系仍然未知。在这里，我们报道了一例类似MacTel-2的抗雌激素性黄斑病变，在停用抗雌激素药物后具有改善的视觉功能和黄斑形态。病例介绍一名53岁的女性，有5个月的中枢视力丧失和双眼畸形的病史。她接受了他莫昔芬的口服治疗，随后接受了托瑞米芬治疗69个月。眼底镜检查，荧光素血管造影和光学相干断层扫描（OCT）显示MacTel-2样发现OU。眼底自发荧光（FAF）在中央凹OU显示超自发荧光。停用抗雌激素药物后，视力，OCT的黄斑形态和FAF的发现逐渐改善。结论在本案中，视力，黄斑形态，停止使用抗雌激素药物后，视网膜色素上皮（RPE）的受损和受损得到改善，这表明抗雌激素药物的视网膜毒性与类似MacTel-2的研究结果之间的关系。从这些结果和先前的观察，由抗雌激素药物引起的感光细胞和RPE细胞的毒性可能会导致类似于MacTel-2的抗雌激素黄斑病的发展。