Access to 1,3-oxazine-2,4-diones/1,3-thiazine-2,4-diones via organocatalytic CO2/COS incorporation into allenamides.,Organic & Biomolecular Chemistry

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Access to 1,3-oxazine-2,4-diones/1,3-thiazine-2,4-diones via organocatalytic CO2/COS incorporation into allenamides.
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-01-09 , DOI: 10.1039/c9ob02398d
Hui Zhou ₁ , Rui Wang ₁ , Hui Zhang ₁ , Wei Chen ₁ , Xiao-Bing Lu ₁

Affiliation

Organocatalyzed [4 + 2] annulation of CO2/COS with allenamides is firstly reported to synthesize 1,3-oxazine-2,4-diones and 1,3-thiazine-2,4-diones in moderate to excellent yields under mild reaction conditions. The catalytic potential of a series of Lewis base CO2 and COS adducts are particularly noted for this process, which features high regio- and chemo-selectivity, step-economy, facile scalability, and easy product derivatization. This study offers the potential for the application of organocatalytic systems for CO2 and COS chemical transformation.

中文翻译：

通过有机催化将CO2 / COS掺入烯丙酰胺中获得1,3-恶嗪-2,4-二酮/ 1,3-噻嗪-2,4-二酮。

首次报道用烯丙酰胺进行有机催化的CO2 / COS [4 + 2]环合反应，在温和的反应条件下，以中等至极好的收率合成了1,3-恶嗪-2,4-二酮和1,3-噻嗪-2,4-二酮。。此过程特别指出了一系列路易斯碱CO2和COS加合物的催化潜力，该特点具有较高的区域选择性和化学选择性，逐步经济性，易扩展性和易于产品衍生化的特点。这项研究为有机催化系统在CO2和COS化学转化中的应用提供了潜力。

更新日期：2020-02-13

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