Designing expanded bipyridinium as redox and optical probes for DNA.,Photochemical & Photobiological Sciences

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Designing expanded bipyridinium as redox and optical probes for DNA.
Photochemical & Photobiological Sciences ( IF 2.7 ) Pub Date : 2020-01-13 , DOI: 10.1039/c9pp00418a
Emanuela Trovato ₁ , Maria Letizia Di Pietro ₂ , Antonino Giannetto ₂ , Gregory Dupeyre ₃ , Philippe P Lainé ₃ , Francesco Nastasi ₂ , Fausto Puntoriero ₂ , Sebastiano Campagna ₂

Affiliation

We report on the light-switch behaviour of two head-to-tail expanded bipyridinium species as a function of their interaction with calf thymus DNA and polynucleotides. In particular, both DNA and polynucleotides containing exclusively adenine or guanine moieties quench the luminescence of the fused expanded bipyridinium species. This behaviour has been rationalized demonstrating that a reductive photoinduced electron transfer process takes place involving both adenine or guanine moieties. The charge separated state so produced recombines in the tens of picoseconds. These results could help in designing new organic substrates for application in DNA probing technology and lab on chip-based sensing systems.

中文翻译：

设计扩展的联吡啶鎓作为DNA的氧化还原和光学探针。

我们报告了两个头到尾扩展联吡啶鎓物种的光开关行为，作为它们与小牛胸腺DNA和多核苷酸相互作用的函数。特别地，仅包含腺嘌呤或鸟嘌呤部分的DNA和多核苷酸都淬灭了融合的扩展联吡啶鎓物种的发光。该行为已经合理化，表明发生了涉及腺嘌呤或鸟嘌呤部分的还原性光诱导电子转移过程。如此产生的电荷分离状态在数十皮秒内重新结合。这些结果可能有助于设计用于基于芯片的传感系统的DNA探测技术和实验室的新型有机底物。

更新日期：2020-02-13

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