Guava is considered as poor man’s apple rich in phytochemicals with medicinal value and hence it is highly consumed. Gas chromatography–mass spectroscopy (GC–MS) analysis of guava leaf extract revealed the presence of various bioactive compounds with antimicrobial, antioxidant, anticancer, and antitumor properties. Hence, it is used in tooth paste formulations along with other ingredients such as Acacia arabica gum powder, stevia herb powder, sea salt, extra virgin coconut oil, peppermint oil in the present study. Three formulations F1, F2 and F3 have been made by varying the concentration of these ingredients and the prepared formulations were studied for their antimicrobial activity and physico-chemical parameters such as pH, abrasiveness, foaming activity, spreading and cleaning ability. Among these, F3 showed significant antioxidant and antimicrobial properties, minimal cytotoxicity, maximum spreadability and very high cleaning ability. This study surmises that the herbal toothpaste formulation is greener, rich in medicinal values and imparts oral hygiene.

中文翻译：

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从番石榴中提取生物活性化合物及其在牙科中的应用。

番石榴被认为是富含植物化学物质的穷人苹果，具有药用价值，因此被大量食用。番石榴叶提取物的气相色谱-质谱（GC-MS）分析显示，存在具有抗微生物，抗氧化剂，抗癌和抗肿瘤特性的各种生物活性化合物。因此，它与其他成分（如阿拉伯树胶）一起用于牙膏配方中本研究中的口香糖粉，甜菊药草粉，海盐，特级初榨椰子油，薄荷油。通过改变这些成分的浓度制备了三种制剂F1，F2和F3，并且研究了所制备的制剂的抗微生物活性和理化参数，例如pH，研磨性，起泡活性，铺展和清洁能力。其中，F3显示出显着的抗氧化剂和抗菌性能，最小的细胞毒性，最大的铺展性和非常高的清洁能力。该研究推测草药牙膏配方更绿色，具有丰富的药用价值并赋予口腔卫生。