Binding of motor proteins to cellular cargoes is regulated by adaptor proteins. HAP1 and GRIP1 are kinesin-1 adaptors that have been implicated individually in the transport of vesicular cargoes in the dendrites of neurons. We find that HAP1a and GRIP1 form a protein complex in the brain, and co-operate to activate the kinesin-1 subunit KIF5C in vitro Based upon this co-operative activation of kinesin-1, we propose a modification to the kinesin activation model that incorporates stabilisation of the central hinge region known to be critical to autoinhibition of kinesin-1.

中文翻译：

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衔接蛋白 HAP1a 和 GRIP1 协同激活 kinesin-1 异构体 KIF5C。

运动蛋白与细胞货物的结合受衔接蛋白的调节。HAP1 和 GRIP1 是 kinesin-1 适配器，它们分别与神经元树突中囊泡货物的运输有关。我们发现 HAP1a 和 GRIP1 在大脑中形成蛋白质复合物，并在体外合作激活 kinesin-1 亚基 KIF5C 基于这种 kinesin-1 的协同激活，我们提出了对 kinesin 激活模型的修改，即结合了已知对 kinesin-1 的自动抑制至关重要的中央铰链区的稳定性。