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pH-Dependent morphology and optical properties of lysine-derived molecular biodynamers
Materials Chemistry Frontiers ( IF 6.0 ) Pub Date : 2019/12/27 , DOI: 10.1039/c9qm00651f
Sangeun Lee 1, 2, 3, 4, 5 , Cansu Kaya 1, 2, 3, 4, 5 , Hongje Jang 5, 6, 7, 8 , Marcus Koch 4, 5, 9, 10, 11 , Brigitta Loretz 4, 5, 12, 13, 14 , Eric Buhler 15, 16, 17, 18, 19 , Claus-Michael Lehr 4, 5, 12, 13, 14 , Anna Katharina Herta Hirsch 1, 2, 3, 4, 5
Affiliation  

Polymerization of carbazole dicarboxaldehydes and lysine derivatives by imine and acylhydrazone formation afforded peptide-derived molecular biodynamers. Characterization of their physicochemical properties revealed an interesting morphology change upon polymerization from monomers forming submicrometer spherical micelles to nanometer-sized rigid-rod-shaped polymeric particles. A combination of light-scattering methods, small-angle neutron scattering, and transmission electron microscopy enabled a detailed investigation of this morphological change. Moreover, we investigated by dynamic and static light scattering how the pH affects the fluorescence and size of the biodynamers. These morphological and pH-dependent changes are expected to open the door to a myriad of applications of molecular biodynamers.

中文翻译:

赖氨酸衍生的分子生物命名物的pH依赖性形态和光学性质

通过形成亚胺和酰基hydr使咔唑二甲醛和赖氨酸衍生物聚合,可得到肽衍生的分子生物名。它们的物理化学性质的表征揭示了聚合反应中有趣的形态变化,从形成亚微米球形胶束的单体到纳米级刚性棒状聚合物颗粒。光散射方法,小角中子散射和透射电子显微镜的组合使得可以对这种形态变化进行详细研究。此外,我们通过动态和静态光散射研究了pH值如何影响生物识别剂的荧光和大小。这些形态学和pH依赖的变化有望为分子生物命名的众多应用打开大门。
更新日期:2020-03-05
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