Anticancer properties, apoptosis and catecholase mimic activities of dinuclear cobalt(II) and copper(II) Schiff base complexes.,Bioorganic Chemistry

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Anticancer properties, apoptosis and catecholase mimic activities of dinuclear cobalt(II) and copper(II) Schiff base complexes.
Bioorganic Chemistry ( IF 4.5 ) Pub Date : 2019-12-29 , DOI: 10.1016/j.bioorg.2019.103561
M Naqi Ahamad ₁ , Khushboo Iman ₁ , Md Kausar Raza ₂ , Manjeet Kumar ₃ , Azaj Ansari ₃ , Musheer Ahmad ₄ , M Shahid ₁

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The present work describes coordination chemistry and biological evaluation of two novel dinuclear complexes [Co2(HL1)2(H2O)2]·8H2O (1) and [Cu2(L2)2] (2) obtained from the Schiff base ligands, H3L1 and H2L2 (formed in situ). The two complexes are characterized by single crystal X-ray, spectral and variable temperature magnetic and theoretical (DFT/TDDFT) analysis. X-ray analysis confirms both the complexes to be dinuclear with distorted octahedral and square pyramidal geometry around Co(II) and Cu(II) ions, respectively. Magnetic studies reveal presence of moderate ferromagnetic interactions in both the complexes with J = 98 (1) and 32 (2) cm-1. The magnetic interactions are further corroborated by DFT studies. Co(II) complex (1) exhibited enhanced catecholase activity with Kcat = 213.48 h-1, which is attributed to the greater extent of charge contribution on Co2+ as compared to Cu2+ as determined by DFT calculations. Furthermore, both the complexes show potent anticancer activity toward HeLa (cervical) and A549 (lung) cancer cell lines with IC50 = 6-7 µM at 48 h, which ascertains both the complexes as better anticancer drugs than cisplatin. Furthermore, 1 and 2 exhibit apoptosis of HeLa cells by demonstrating nuclear blebbings with shrinking morphology. Hence, the present complexes could be employed as a model for metalloenzymes as well as potential anticancer substituents of cisplatin in future course.

中文翻译：

双核钴（II）和铜（II）Schiff碱复合物的抗癌特性，凋亡和儿茶酚酶模拟活性。

本工作描述了从席夫碱配体H3L1和H3L1获得的两种新型双核配合物[Co2（HL1）2（H2O）2]·8H2O（1）和[Cu2（L2）2]（2）的配位化学和生物学评估。 H2L2（原位形成）。两种配合物的特征在于单晶X射线，光谱和可变温度的磁和理论（DFT / TDDFT）分析。X射线分析证实这两种络合物都是双核的，分别在Co（II）和Cu（II）离子周围具有扭曲的八面体和方形锥体形状。磁性研究表明在J = 98（1）和32（2）cm-1的两种配合物中均存在适度的铁磁相互作用。DFT研究进一步证实了磁性相互作用。Co（II）配合物（1）的儿茶酚酶活性增强，Kcat = 213.48 h-1，这是由于通过DFT计算确定，与Cu2 +相比，Co2 +上的电荷贡献程度更大。此外，两种复合物在48 h时对HeLa（宫颈）和A549（肺癌）癌细胞系均显示有效的抗癌活性，IC50 = 6-7 µM，这两种复合物均被确定为比顺铂更好的抗癌药物。此外，1和2通过证明具有缩小形态的核起泡而表现出HeLa细胞的凋亡。因此，本发明的复合物可以用作未来将来金属酶以及顺铂潜在的抗癌取代基的模型。可以确定这两种复合物都比顺铂更好。此外，1和2通过证明具有缩小形态的核起泡而表现出HeLa细胞的凋亡。因此，本发明的复合物可以用作未来将来金属酶以及顺铂潜在的抗癌取代基的模型。可以确定这两种复合物都比顺铂更好。此外，1和2通过证明具有缩小形态的核起泡而表现出HeLa细胞的凋亡。因此，本发明的复合物可以用作未来将来金属酶以及顺铂潜在的抗癌取代基的模型。

更新日期：2019-12-29

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