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Microfluidic systems for cancer diagnostics.
Current Opinion in Biotechnology ( IF 7.1 ) Pub Date : 2019-12-28 , DOI: 10.1016/j.copbio.2019.11.022 Jose L Garcia-Cordero 1 , Sebastian J Maerkl 2
Current Opinion in Biotechnology ( IF 7.1 ) Pub Date : 2019-12-28 , DOI: 10.1016/j.copbio.2019.11.022 Jose L Garcia-Cordero 1 , Sebastian J Maerkl 2
Affiliation
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Although not employed in the clinic as of yet, microfluidic systems are likely to become a key technology for cancer diagnostics and prognosis. Microfluidic devices have been developed for the analysis of various biomarkers including circulating tumor cells, cell-free DNA, exosomes, and proteins, primarily in liquid biopsies such as serum, plasma, and whole blood, avoiding the need for tumor tissue biopsies. Here, we summarize microfluidic technological advances that are used in cancer diagnosis, prognosis, and to monitor its progression and recurrence, that will likely lead to personalized therapies. In some cases, integrated microfluidic technologies, coupled with biosensors, are proving to be more sensitive and precise in the detection of cancer biomarkers than conventional assays. Based on the current state-of-the-art and the rapid progress over the past decade, we also briefly discuss the next evolutionary steps that these technologies are likely to take.
中文翻译：
用于癌症诊断的微流体系统。
尽管目前尚未在临床中使用，但微流体系统可能会成为癌症诊断和预后的关键技术。已经开发出微流体装置来分析各种生物标记物，包括循环的肿瘤细胞，无细胞DNA，外泌体和蛋白质，主要是在液体活检组织（例如血清，血浆和全血）中进行分析，从而避免了对肿瘤组织活检组织的需要。在这里，我们总结了用于癌症诊断，预后并监测其进展和复发的微流控技术进展，这很可能会导致个性化疗法。在某些情况下，事实证明，集成的微流技术与生物传感器相结合，在检测癌症生物标志物方面比常规分析更为灵敏和精确。
更新日期：2020-04-20
中文翻译：
用于癌症诊断的微流体系统。
尽管目前尚未在临床中使用，但微流体系统可能会成为癌症诊断和预后的关键技术。已经开发出微流体装置来分析各种生物标记物，包括循环的肿瘤细胞，无细胞DNA，外泌体和蛋白质，主要是在液体活检组织（例如血清，血浆和全血）中进行分析，从而避免了对肿瘤组织活检组织的需要。在这里，我们总结了用于癌症诊断，预后并监测其进展和复发的微流控技术进展，这很可能会导致个性化疗法。在某些情况下，事实证明，集成的微流技术与生物传感器相结合，在检测癌症生物标志物方面比常规分析更为灵敏和精确。
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