Lonicera japonica Thunb. has been widely used as food ingredients and healthy drinks in the Asian countries, which was reported to possess some good activities. However, it remains unknown in the immunomodulation of Lonicera japonica polysaccharides (LJP) on allergic rhinitis (AR). This study aimed to investigate the impact of LJP on ovalbumin-induced AR in BALB/c mice model. LJP significantly inhibited AR symptoms and eosinophil number in nasal mucosa. Besides, the increased serum levels of IgE, TNF-α, IL-1β and IL-17 were markedly decreased when AR mice were treated with LJP. The mRNA expression levels of IL-4, IL-5, IL-6, IL-17, IL-23, ROR-γt and STAT3 in OVA group were increased, and SOCS3 was reduced, while LJP inhibited the changes. The present study indicated that LJP suppressed the inflammatory response in AR sensitized by ovalbumin, showing that LJP has the potential to treat AR through the regulation of Th17 cells.

金银花藤。在亚洲国家已被广泛用作食品成分和健康饮料，据报道具有良好的活性。然而，在忍冬忍冬的免疫调节中仍然未知。多糖（LJP）对过敏性鼻炎（AR）。这项研究旨在调查LJP对BALB / c小鼠模型中卵白蛋白诱导的AR的影响。LJP显着抑制鼻粘膜的AR症状和嗜酸性粒细胞数。此外，用LJP治疗AR小鼠后，血清IgE，TNF-α，IL-1β和IL-17的升高明显降低。OVA组IL-4，IL-5，IL-6，IL-17，IL-23，ROR-γt和STAT3的mRNA表达水平升高，而SOCS3降低，而LJP抑制该变化。本研究表明，LJP抑制了卵白蛋白致敏的AR的炎症反应，表明LJP具有通过调节Th17细胞治疗AR的潜力。