Photodegradation of (E)- and (Z)-Endoxifen in water by ultraviolet light: Efficiency, kinetics, by-products, and toxicity assessment.,Water Research

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Photodegradation of (E)- and (Z)-Endoxifen in water by ultraviolet light: Efficiency, kinetics, by-products, and toxicity assessment.
Water Research ( IF 11.4 ) Pub Date : 2019-12-29 , DOI: 10.1016/j.watres.2019.115451
Marina Ariño Martin ₁ , Jayaraman Sivaguru ₂ , John McEvoy ₃ , Prinpida Sonthiphand ₄ , Andre Delorme ₅ , Eakalak Khan ₆

Affiliation

Endoxifen is an effective metabolite of a common chemotherapy agent, tamoxifen. Endoxifen, which is toxic to aquatic animals, has been detected in wastewater treatment plant (WWTP) effluent. This research investigates ultraviolet (UV) radiation (253.7 nm) application to degrade (E)- and (Z)-endoxifen in water and wastewater and phototransformation by-products (PBPs) and their toxicity. The effects of light intensity, pH and initial concentrations of (E)- and (Z)-endoxifen on the photodegradation rate were examined. Endoxifen in water was eliminated ≥99.1% after 35 s of irradiation (light dose of 598.5 mJ cm-2). Light intensity and initial concentrations of (E)- and (Z)-endoxifen exhibited positive trends with the photodegradation rates while pH had no effect. Photodegradation of (E)- and (Z)-endoxifen in water resulted in three PBPs. Toxicity assessments through modeling of the identified PBPs suggest higher toxicity than the parent compounds. Photodegradation of (E)- and (Z)-endoxifen in wastewater at light doses used for disinfection in WWTPs (16, 30 and 97 mJ cm-2) resulted in reductions of (E)- and (Z)-endoxifen from 30 to 71%. Two of the three PBPs observed in the experiments with water were detected in the wastewater experiments. Therefore, toxic compounds are potentially generated at WWTPs by UV disinfection if (E)- and (Z)-endoxifen are present in treated wastewater.

中文翻译：

紫外线对水中的（E）-和（Z）-内氧芬进行光降解：效率，动力学，副产物和毒性评估。

恩多昔芬是常见化疗药物他莫昔芬的有效代谢产物。在废水处理厂（WWTP）的废水中已检测到对水生动物有毒的内氧芬。这项研究调查了紫外线（UV）辐射（253.7 nm）的应用，以降解水和废水中的（E）-和（Z）-内氧芬和光转化副产物（PBPs）及其毒性。考察了光强度，pH和（E）-和（Z）-内氧芬的初始浓度对光降解速率的影响。辐照35 s（光剂量为598.5 mJ cm-2）后，水中的内毒素清除率为≥99.1％。（E）-和（Z）-内多芬的光强度和初始浓度与光降解速率呈正趋势，而pH值无影响。水中（E）-（Z）-endoxifen的光降解导致三个PBP。通过对已鉴定的PBP建模进行的毒性评估表明，毒性比母体化合物高。污水处理厂中用于消毒的光剂量（16、30和97 mJ cm-2）的废水中（E）-和（Z）-endoxifen的光降解导致（E）-和（Z）-endoxifen从30降低到30 71％。在废水实验中检测到了用水进行的三个PBP中的两个。因此，如果处理后的废水中存在（E）-和（Z）-内氧芬，则紫外线消毒可能会在污水处理厂产生有毒化合物。在废水实验中检测到了用水进行的三个PBP中的两个。因此，如果处理后的废水中存在（E）-和（Z）-内氧芬，则紫外线消毒可能会在污水处理厂产生有毒化合物。在废水实验中检测到了用水进行的三个PBP中的两个。因此，如果处理后的废水中存在（E）-和（Z）-内氧芬，则紫外线消毒可能会在污水处理厂产生有毒化合物。

更新日期：2019-12-29

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