The anti-quorum sensing property of terpene phenols/alcohols and their deoxyglucosides was evaluated qualitatively against Pseudomonas aeruginosa and Chromobacterium violaceum by agar well diffusion method, and their antimutagenic activity was tested by Ames test. The 2,3-unsaturated and 2,3-dideoxy 1-O-glucoside derivatives demonstrated higher inhibitory zones compared to those for the parent molecules. MIC values indicated that the derivatives of carvacrol (1.0–1.2 μmol/ml) and thymol (1.0–1.2 μmol/ml) were more effective than the other compounds (1.2–2.0 μmol/ml). The anti-quorum sensing potential of derivatives was demonstrated by the reduction in the production of pyocyanin (75–95%) and violacein (76–98%) at sub-MIC concentrations. The 2,3-unsaturated 1-O-glucosides of carvacrol and thymol exhibited superior antimutagenic properties, and 2,3-unsaturated 1-O-glucoside of thymol showed 87.7% inhibition of MMS induced mutation in Salmonella typhimurium TA 1538 at 1 μmol/plate concentration. The superior anti-quorum and antimutagenic activities exhibited by these derivatives indicate their potential application as food preservatives.

通过琼脂良好扩散法定性评价了萜烯酚/醇及其脱氧葡萄糖苷的抗群体感应特性，并通过琼脂良好扩散法对铜绿假单胞菌和紫罗兰色杆菌进行了定居评价，并通过Ames试验测试了它们的抗诱变活性。与母体分子相比，2,3-不饱和和2,3-二脱氧1- O-葡萄糖苷衍生物表现出更高的抑制区。MIC值表明香芹酚（1.0–1.2μmol/ ml）和百里酚（1.0–1.2μmol/ ml）的衍生物比其他化合物（1.2–2.0μmol/ ml）更有效。低于MIC浓度时，绿脓素（75–95％）和紫堇青素（76–98％）的产量降低，证明了衍生物具有抗群体感应的潜力。香芹酚和百里香酚的2,3-不饱和1- O-葡糖苷具有优异的抗诱变特性，百里香酚的2,3-不饱和1- O-葡糖苷对鼠伤寒沙门氏菌TA 1538中MMS诱导的突变的抑制率为87.7％，1μmol/板浓度。这些衍生物表现出的优异的抗定座和抗诱变活性表明它们作为食品防腐剂的潜在应用。