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Analysis of tumor markers in pleural effusion and serum to verify the correlations between serum tumor markers and tumor size, TNM stage of lung adenocarcinoma.
Cancer Medicine ( IF 2.9 ) Pub Date : 2019-12-27 , DOI: 10.1002/cam4.2809 Zhongqing Chen 1 , Ying Wang 1 , Min Fang 1
Cancer Medicine ( IF 2.9 ) Pub Date : 2019-12-27 , DOI: 10.1002/cam4.2809 Zhongqing Chen 1 , Ying Wang 1 , Min Fang 1
Affiliation
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BACKGROUND
The study of tumor markers (TM) in pleural effusion (PE) was not extensive.
METHODS
TM in PE and serum were analyzed to determine whether TM was expressed in intrathoracic and extrathoracic tissues. To further verify the correlations between serum TM and tumor size, TNM stage of lung adenocarcinoma.
RESULTS
Serum AFP was not correlated with tumor size, T stage, N stage, and M stage (P > .05). Serum CEA, serum CA125, serum CA15-3 were positively correlated with tumor size, T stage, N stage, M stage (P < .05). Serum CA19-9 was not significantly correlated with tumor size and T stage (P > .05), but was positively correlated with N stage and M stage (P < .05). The levels of PE CEA, PE CA125, PE CA15-3 were higher than those of serum CEA, serum CA125, serum CA15-3 (all P < .05). The level of PE AFP was lower than that of serum AFP (P < .05). The level of PE CA19-9 was not significantly different from that of serum CA19-9 (P > .05). The positive rates of PE CEA and PE CA125 were higher than those of serum CEA and serum CA125 (P < .05). The positive rates of PE AFP, PE CA15-3, PE CA19-9 were not significantly different from those of serum AFP, serum CA15-3, serum CA19-9 (P > .05).PE CEA, PE CA125, PE CA15-3 were moderately positively correlated with serum CEA, serum CA125, serum CA15-3, respectively (r = 0.597; r = 0.46; r = 0.583, all P < .05). However, PE AFP and PE CA19-9 were very strongly positively correlated with serum AFP and serum CA19-9, respectively (r = 0.888; r = 0.874, all P < .05).
CONCLUSION
The expression characteristics of TM in PE and serum supported the correlations between serum TM and tumor size, TNM stage of lung adenocarcinoma.
中文翻译：
分析胸腔积液和血清中的肿瘤标志物，验证血清肿瘤标志物与肺腺癌肿瘤大小、TNM分期的相关性。
背景胸腔积液（PE）中肿瘤标志物（TM）的研究并不广泛。方法分析PE和血清中的TM以确定TM是否在胸腔内和胸外组织中表达。进一步验证血清TM与肺腺癌肿瘤大小、TNM分期的相关性。结果 血清 AFP 与肿瘤大小、T 分期、N 分期和 M 分期无关（P > .05）。血清CEA、血清CA125、血清CA15-3与肿瘤大小、T分期、N分期、M分期呈正相关（P < .05）。血清CA19-9与肿瘤大小和T分期不显着相关（P > .05），但与N分期和M分期呈正相关（P < .05）。 PE CEA、PE CA125、PE CA15-3 水平高于血清 CEA、血清 CA125、血清 CA15-3（均 P < .05）。 PE AFP 水平低于血清 AFP (P < .05)。 PE CA19-9 水平与血清 CA19-9 水平无显着差异（P > .05）。 PE CEA和PE CA125的阳性率高于血清CEA和血清CA125（P < .05）。 PE AFP、PE CA15-3、PE CA19-9 阳性率与血清 AFP、血清 CA15-3、血清 CA19-9 阳性率差异无统计学意义（P > .05）。PE CEA、PE CA125、PE CA15 -3 分别与血清 CEA、血清 CA125、血清 CA15-3 呈中度正相关（r = 0.597；r = 0.46；r = 0.583，均 P < .05）。然而，PE AFP 和 PE CA19-9 分别与血清 AFP 和血清 CA19-9 呈极强正相关（r = 0.888；r = 0.874，所有 P < .05）。结论 PE和血清中TM的表达特征支持血清TM与肺腺癌肿瘤大小、TNM分期的相关性。
更新日期：2019-12-29
中文翻译：
分析胸腔积液和血清中的肿瘤标志物，验证血清肿瘤标志物与肺腺癌肿瘤大小、TNM分期的相关性。
背景胸腔积液（PE）中肿瘤标志物（TM）的研究并不广泛。方法分析PE和血清中的TM以确定TM是否在胸腔内和胸外组织中表达。进一步验证血清TM与肺腺癌肿瘤大小、TNM分期的相关性。结果 血清 AFP 与肿瘤大小、T 分期、N 分期和 M 分期无关（P > .05）。血清CEA、血清CA125、血清CA15-3与肿瘤大小、T分期、N分期、M分期呈正相关（P < .05）。血清CA19-9与肿瘤大小和T分期不显着相关（P > .05），但与N分期和M分期呈正相关（P < .05）。 PE CEA、PE CA125、PE CA15-3 水平高于血清 CEA、血清 CA125、血清 CA15-3（均 P < .05）。 PE AFP 水平低于血清 AFP (P < .05)。 PE CA19-9 水平与血清 CA19-9 水平无显着差异（P > .05）。 PE CEA和PE CA125的阳性率高于血清CEA和血清CA125（P < .05）。 PE AFP、PE CA15-3、PE CA19-9 阳性率与血清 AFP、血清 CA15-3、血清 CA19-9 阳性率差异无统计学意义（P > .05）。PE CEA、PE CA125、PE CA15 -3 分别与血清 CEA、血清 CA125、血清 CA15-3 呈中度正相关（r = 0.597；r = 0.46；r = 0.583，均 P < .05）。然而，PE AFP 和 PE CA19-9 分别与血清 AFP 和血清 CA19-9 呈极强正相关（r = 0.888；r = 0.874，所有 P < .05）。结论 PE和血清中TM的表达特征支持血清TM与肺腺癌肿瘤大小、TNM分期的相关性。
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