The Binge Drinking (BD) pattern of alcohol consumption, prevalent in adolescents and young adults, has been associated with memory impairment. In addition, evidence shows that alcohol abuse causes neuroinflammation, which may contribute to the brain damage produced by alcohol and explain its cognitive consequences. In this study, we evaluated the effectiveness of the anti-inflammatory indomethacin in counteracting the memory impairment produced by alcohol (ethanol) in adolescent mice of both sexes. Animals were randomly assigned to one of four groups for each sex: SS (saline + saline), SA (saline + alcohol), SI (saline + indomethacin) and AI (alcohol + indomethacin). They were injected acutely (Experiment 1) or chronically intermittent (Experiment 2) with saline, ethanol (3 g/kg) and indomethacin (10 mg/kg). All subjects were evaluated in an inhibitory avoidance task 96 h after treatment. With acute administration, SA groups showed significantly lower Test latencies than SS groups, while AI groups had similar latencies to controls. The chronic-intermittent administration of alcohol, an animal model of BD, produced significant emotional memory impairment -blocking learning in males- which was counteracted by indomethacin, as the AI groups had similar latencies to the SS groups. No significant differences were observed in locomotor activity or analgesia. In conclusion, alcohol BD (one or several episodes) impairs emotional memory in mice. This impairment is not secondary to the effects of alcohol BD on locomotor activity or pain sensitivity, and it is counteracted by indomethacin. Therefore, the memory impairment produced by alcohol BD seems to be mediated, in part, by neuroinflammatory processes. These findings open a window for new treatments for alcohol use disorders.

中文翻译：

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消炎消炎痛消灭了因在小鼠中暴饮暴食而产生的情绪记忆障碍。

饮酒的狂饮（BD）模式在青少年和年轻人中普遍存在，与记忆力受损有关。此外，有证据表明，酗酒会引起神经炎症，这可能会导致酒精引起的脑部损伤并解释其认知后果。在这项研究中，我们评估了消炎消炎痛在抵消酒精（乙醇）在男女两性的青春期小鼠中产生的记忆障碍的有效性。按性别将动物随机分为四组之一：SS（盐水+盐水），SA（盐水+酒精），SI（盐水+消炎痛）和AI（酒精+消炎痛）。分别给他们注射生理盐水，乙醇（3 g / kg）和消炎痛（10 mg / kg）的急性（实验1）或慢性间歇性（实验2）。治疗后96小时，对所有受试者进行抑制性避免任务评估。急性给药后，SA组的测试潜伏期明显低于SS组，而AI组的潜伏期与对照组相似。长期间歇性服用酒精（一种BD动物模型）会产生明显的情绪记忆障碍-阻碍男性的学习-这被消炎痛抵消了，因为AI组的潜伏期与SS组的潜伏期相似。运动活动或镇痛方面未观察到显着差异。总之，酒精性BD（一次或多次发作）会损害小鼠的情绪记忆。这种损害不是继酒精BD对运动活动或疼痛敏感性的影响之后的，并且由吲哚美辛抵消。所以，酒精BD产生的记忆障碍似乎部分是由神经炎症过程介导的。这些发现为酒精使用障碍的新疗法打开了一个窗口。