Performance of polyvinyl pyrrolidone-isatis root antibacterial wound dressings produced in situ by handheld electrospinner.,Colloids and Surfaces B: Biointerfaces

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Performance of polyvinyl pyrrolidone-isatis root antibacterial wound dressings produced in situ by handheld electrospinner.
Colloids and Surfaces B: Biointerfaces ( IF 5.4 ) Pub Date : 2019-12-28 , DOI: 10.1016/j.colsurfb.2019.110766
Wen-Hao Dong ₁ , Jia-Xu Liu ₁ , Xiao-Ju Mou ₁ , Guo-Sai Liu ₁ , Xiao-Wei Huang ₁ , Xu Yan ₂ , Xin Ning ₂ , Stephen J Russell ₃ , Yun-Ze Long ₄

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Antibacterial dressings are an increasingly important tool for the prevention and management of wound infections, particularly in light of concerns surrounding conventional drug-resistant antibiotics. Handheld electrospinning devices provide opportunities for the rapid application of antibacterial dressing materials to wounds, but spinning formulations need to be compatible with live biological surfaces. We report the development of a new antibacterial formulation compatible with handheld electrospinning, and its manufacture directly on a wound site. Nanofibrous dressing mats were produced from polyvinyl pyrrolidone (PVP) containing isatis root (Indigowoad root or Ban-Lan-Gen), a traditional Chinese medicine, commonly used for the treatment of infectious disease. The resulting wound dressing mats of PVP/isatis root exhibited well-defined fibrous structures and excellent surface wetting, and permeability characteristics. The presence of isatis root conferred antibacterial activity against gram negative and gram positive strains. Moreover, in a Kunming mouse skin injury model, direct electrospinning of PVP/isatis root formulations on to wound sites produced near complete wound closure after 11 days and epidermal repair in histological studies.

中文翻译：

手持式静电纺丝机现场生产的聚乙烯吡咯烷酮-依蒂斯根抗菌伤口敷料的性能。

抗菌敷料是预防和控制伤口感染的越来越重要的工具，尤其是考虑到围绕常规耐药抗生素的关注。手持式静电纺丝设备为将抗菌敷料材料快速应用于伤口提供了机会，但是纺丝配方必须与活生物表面兼容。我们报告了与手持式静电纺丝兼容的新型抗菌制剂的开发，并直接在伤口部位生产。用含有板蓝根（靛蓝根或Ban-Lan-Gen）的聚乙烯吡咯烷酮（PVP）生产纳米纤维敷料垫，这是一种传统中药，通常用于治疗传染病。所得的PVP / isatis根伤口敷料垫具有定义明确的纤维结构，并具有出色的表面润湿性和渗透性。板蓝根的存在赋予了革兰氏阴性和革兰氏阳性菌株的抗菌活性。此外，在昆明小鼠皮肤损伤模型中，将PVP / isatis根制剂直接静电纺丝至伤口部位会在11天后完全闭合伤口，并在组织学研究中进行表皮修复。

更新日期：2019-12-29

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