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In Situ Ligand-Directed Growth of Gold Nanoparticles in Biological Tissues.
Nano Letters ( IF 9.6 ) Pub Date : 2019-12-27 , DOI: 10.1021/acs.nanolett.9b04911
Chuanqi Peng 1 , Mengxiao Yu 1 , Jie Zheng 1
Affiliation  

Fundamental understandings and precise control of nanoparticle growth in the complex biological environment are crucial to broadening their potential applications in tissue imaging. Herein, we report that glutathione (GSH), a widely used capping ligand for precise control of the size of gold nanoparticle (AuNP) down to single-atom level in test tubes, can also be used to direct the selective growth of the AuNPs in the mitochondria of renal tubule cells as well as hippocampus cells in the tissues. Precise control of this growth process can lead to the formation of both ultrasmall AuNPs with near-infrared luminescence and large plasmonic AuNPs. The observed selective growth of the AuNPs is likely due to unique GSH storage function of the mitochondria. Using a different ligand, β-glucose thiol, we also found that the brush border of the intestine for glucose absorption became the major site for the growth of luminescent AuNPs. These findings suggest that selective growth of AuNPs in the biological tissues can indeed be directed with specific ligands, opening up a new avenue to tissue labeling and future development of artificial bionano hybrid systems.

中文翻译:

生物组织中金纳米颗粒的原位配体定向生长。

对复杂生物环境中纳米颗粒生长的基本理解和精确控制对于扩大其在组织成像中的潜在应用至关重要。在此,我们报道谷胱甘肽(GSH)是一种广泛使用的封端配体,用于在试管中将金纳米颗粒(AuNP)的尺寸精确控制至单原子水平,也可用于指导金纳米颗粒在试管中的选择性生长。肾小管细胞的线粒体以及组织中的海马细胞。精确控制这一生长过程可以形成具有近红外发光的超小型金纳米粒子和大型等离子体金纳米粒子。观察到的 AuNP 的选择性生长可能是由于线粒体独特的 GSH 存储功能。使用不同的配体β-葡萄糖硫醇,我们还发现用于葡萄糖吸收的肠道刷状缘成为发光AuNPs生长的主要位点。这些发现表明,AuNP 在生物组织中的选择性生长确实可以通过特定配体进行定向,为组织标记和人工生物纳米混合系统的未来发展开辟了一条新途径。
更新日期:2020-01-06
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