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Amphiphilic nature of polyethylene glycols and their role in medical research
Polymer Testing ( IF 5.0 ) Pub Date : 2020-02-01 , DOI: 10.1016/j.polymertesting.2019.106316
Zahoor Ahmad Parray , Md Imtaiyaz Hassan , Faizan Ahmad , Asimul Islam

Abstract Background Polyethylene glycol (PEG) is a polyether compound which is an excellent candidate to study possible specific interactions of protein-polymer systems at the atomic level. Such studies would be beneficial in obtaining a more thorough understanding of PEG-protein interactions and might help to explain PEG's effects on protein behavior when used as a crowder. Scope of review PEGs has been called double edged sword showing assorted effects on the protein due its hydrophilic, hydrophobic and amphiphatic nature. It has been observed that the stabilization of the protein due to PEGs is because of exclusion volume effect (hard core interactions) shown by the higher molecular sizes of the crowder, however there are soft (chemical) interactions also which leads to destabilization of proteins. Most of low molecular size PEGs are noticed to destabilize proteins due to soft interactions. General significance Here, the core characteristics of the polyethylene glycols that are responsible for the various interactions with proteins and trying to delineate the behaviour of PEGs being ambiguous, are discussed. To conclude its paradox nature being a factual inert molecule or not, many different reports of PEG interactions with various proteins are clubbed together. In addition, owing to low toxicity, high polarity, high water solubility, typically unhydrolysing or undeteriorating characteristics, it has a practical significance in pharmaceutical and cosmetic industries, and in the research field on which this review shall enlighten from earlier to now.

中文翻译:

聚乙二醇的两亲性质及其在医学研究中的作用

摘要 背景聚乙二醇 (PEG) 是一种聚醚化合物,是在原子水平上研究蛋白质-聚合物系统可能的特定相互作用的极好候选者。此类研究将有助于更深入地了解 PEG-蛋白质相互作用,并可能有助于解释 PEG 在用作拥挤时对蛋白质行为的影响。审查范围 PEG 被称为双刃剑,由于其亲水性、疏水性和两亲性,对蛋白质显示出各种影响。已经观察到,由 PEG 引起的蛋白质的稳定性是由于拥挤的较高分子大小显示的排阻体积效应(硬核相互作用),但是也存在导致蛋白质不稳定的软(化学)相互作用。由于软相互作用,大多数低分子 PEG 会破坏蛋白质的稳定性。一般意义 这里讨论了负责与蛋白质的各种相互作用并试图描绘 PEG 行为不明确的聚乙二醇的核心特征。总结其悖论性质是否是事实上的惰性分子,许多关于 PEG 与各种蛋白质相互作用的不同报告被拼凑在一起。此外,由于其低毒、高极性、高水溶性、典型的不水解或不变质等特点,在医药和化妆品行业具有现实意义,在本综述从前到今的研究领域也具有重要意义。讨论了负责与蛋白质的各种相互作用的聚乙二醇的核心特征,并试图描述 PEG 的行为模棱两可。总结其悖论性质是否是事实上的惰性分子,许多关于 PEG 与各种蛋白质相互作用的不同报告被拼凑在一起。此外,由于其低毒、高极性、高水溶性、典型的不水解或不变质等特点,在医药和化妆品行业具有现实意义,在本综述从前到今的研究领域也具有重要意义。讨论了负责与蛋白质的各种相互作用的聚乙二醇的核心特征,并试图描述 PEG 的行为模棱两可。总结其悖论性质是否是一种事实上的惰性分子,许多关于 PEG 与各种蛋白质相互作用的不同报告被拼凑在一起。此外,由于其低毒、高极性、高水溶性、典型的不水解或不变质等特点,在医药和化妆品行业具有现实意义,在本综述从前到今的研究领域也具有重要意义。总结其悖论性质是否是一种事实上的惰性分子,许多关于 PEG 与各种蛋白质相互作用的不同报告被拼凑在一起。此外,由于其低毒、高极性、高水溶性、典型的不水解或不变质等特点,在医药和化妆品行业具有现实意义,在本综述从前到今的研究领域也具有重要意义。总结其悖论性质是否是一种事实上的惰性分子,许多关于 PEG 与各种蛋白质相互作用的不同报告被拼凑在一起。此外,由于其低毒、高极性、高水溶性、典型的不水解或不变质等特点,在医药和化妆品行业具有现实意义,在本综述从前到今的研究领域也具有重要意义。
更新日期:2020-02-01
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