Allergic diseases not only bring serious economic burden to the patients, but also consume a lot of substantial resources of social medical systems. Thus, the prevention and treatment of allergic diseases are imperative. In this study, the anti-degranulation activity of herbal formula was evaluated using the rat basophil leukemia cells (RBL-2H3) as in vitro model. The morphological and biophysical properties of RBL-2H3 cells before and after treatment with herbal formula were also determined. Notably, the herbal formula exhibits clearly inhibited degranulation by RBL-2H3 cells in a concentration-dependent manner without cytotoxic effect. Therefore, this herbal formula can be used as an alternative and promising therapeutic agent to ameliorate allergic diseases.

过敏性疾病不仅给患者带来了沉重的经济负担，而且还消耗了大量社会医疗系统的资源。因此，预防和治疗过敏性疾病势在必行。在这项研究中，使用大鼠嗜碱性粒细胞白血病细胞（RBL-2H3）作为体外模型评估了草药配方的抗脱粒活性。还确定了用草药配方处理之前和之后的RBL-2H3细胞的形态和生物物理特性。值得注意的是，该草药配方显示出RBL-2H3细胞以浓度依赖性方式明显抑制了脱粒，而没有细胞毒性作用。因此，该草药配方可用作缓解过敏性疾病的替代和有前途的治疗剂。