Multiparametric MRI is a remarkable imaging method for the assessment of patho-physiological processes. In particular, brain tumor characterization has taken advantage of the development of advanced techniques such as Diffusion- (DWI) and Perfusion- (PWI) Weighted Imaging, but a thorough analysis of meningiomas is still lacking despite the variety of computational methods proposed. We compute perfusion and diffusion parametric maps relying on a well-defined methodological workflow, investigating possible correlations between pure and diffusion-based perfusion parameters in a cohort of 26 patients before proton therapy. A preliminary investigation of meningioma staging biomarkers based on IntraVoxel Incoherent Motion and Dynamic Susceptibility Contrast is also reported. We observed significant differences between the gross target volume and the normal appearing white matter for every investigated parameter, confirming the higher vascularization of the neoplastic tissue. DWI and PWI parameters appeared to be weakly correlated and we found that diffusion parameters - the perfusion fraction in particular - could be promising biomarkers for tumor staging.

中文翻译：

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脑膜瘤肿瘤的灌注和扩散：动态敏感性对比和IntraVoxel非相干运动MRI的初步多参数分析。

多参数MRI是评估病理生理过程的出色成像方法。尤其是，脑肿瘤的表征已经利用了诸如弥散（DWI）和灌注（PWI）加权成像等先进技术的发展，但是尽管提出了多种计算方法，但仍缺乏对脑膜瘤的透彻分析。我们依靠定义明确的方法工作流程来计算灌注和扩散参数图，研究在质子治疗之前的26名患者中研究纯和基于扩散的灌注参数之间的可能相关性。还报道了基于IntraVoxel不相干运动和动态敏感性对比对脑膜瘤分期生物标志物进行的初步研究。我们观察到每个研究参数的总目标体积与正常出现的白质之间存在显着差异，证实了肿瘤组织的更高血管形成。DWI和PWI参数似乎相关性较弱，我们发现扩散参数-特别是灌注分数-可能是肿瘤分期的有前途的生物标志物。