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Impact of the structure-activity relationship of AHL analogues on quorum sensing in Gram-negative bacteria.
Bioorganic & Medicinal Chemistry ( IF 3.3 ) Pub Date : 2019-12-28 , DOI: 10.1016/j.bmc.2019.115282 Christiane Chbib 1
Bioorganic & Medicinal Chemistry ( IF 3.3 ) Pub Date : 2019-12-28 , DOI: 10.1016/j.bmc.2019.115282 Christiane Chbib 1
Affiliation
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With the emergence of microbial resistance pathogens, recent research aims at studying new mechanisms of action of antibiotics. This review discusses the mechanisms and types of quorum sensing (QS) inhibitors in Gram negative bacteria. It illustrates all published data available in literature pertaining to novel compounds that showed activity against different targets in the quorum sensing pathways in Gram negative bacteria. A systemic overview has been conducted by searching PubMed, Medline, and the Cochrane Library and data extraction of all quorum sensing inhibitors with their mechanisms of action have been collected. This review will focus on signaling autoinducer AI-1 in Gram negative bacteria. The biological activity of the antagonists is mainly reported as IC50 (the concentration of an inhibitor where the response is reduced by half).
中文翻译：
AHL类似物的构效关系对革兰氏阴性细菌群体感应的影响。
随着微生物抗性病原体的出现，最近的研究旨在研究抗生素的新作用机理。这篇综述讨论了革兰氏阴性细菌中群体感应（QS）抑制剂的机制和类型。它说明了所有文献中与新颖化合物相关的所有公开数据，这些化合物在革兰氏阴性细菌的群体感应途径中表现出针对不同靶标的活性。通过搜索PubMed，Medline和Cochrane库进行了系统的概述，并已收集了所有群体感应抑制剂及其作用机理的数据。这篇综述将着重于革兰氏阴性细菌中信号传导自动诱导物AI-1的研究。拮抗剂的生物活性主要报告为IC50（反应降低一半的抑制剂浓度）。
更新日期：2019-12-29
中文翻译：
AHL类似物的构效关系对革兰氏阴性细菌群体感应的影响。
随着微生物抗性病原体的出现，最近的研究旨在研究抗生素的新作用机理。这篇综述讨论了革兰氏阴性细菌中群体感应（QS）抑制剂的机制和类型。它说明了所有文献中与新颖化合物相关的所有公开数据，这些化合物在革兰氏阴性细菌的群体感应途径中表现出针对不同靶标的活性。通过搜索PubMed，Medline和Cochrane库进行了系统的概述，并已收集了所有群体感应抑制剂及其作用机理的数据。这篇综述将着重于革兰氏阴性细菌中信号传导自动诱导物AI-1的研究。拮抗剂的生物活性主要报告为IC50（反应降低一半的抑制剂浓度）。
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