Uveal melanoma is the most common primary malignancy of the eye, and a number of discoveries in the last decade have led to a more thorough molecular characterization of this cancer. However, the prognosis remains dismal for patients with metastases, and there is an urgent need to identify treatments that are effective for this stage of disease. Animal models are important tools for preclinical studies of uveal melanoma. A variety of models exist, and they have specific advantages, disadvantages, and applications. In this review article, these differences are explored in detail, and ideas for new models that might overcome current challenges are proposed.

中文翻译：

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葡萄膜黑色素瘤小鼠模型：优点、缺点和未来方向。


葡萄膜黑色素瘤是眼睛最常见的原发性恶性肿瘤，过去十年的许多发现使人们对这种癌症进行了更彻底的分子表征。然而，转移患者的预后仍然很差，迫切需要找到对该阶段疾病有效的治疗方法。动物模型是葡萄膜黑色素瘤临床前研究的重要工具。存在多种模型，它们具有特定的优点、缺点和应用。在这篇评论文章中，详细探讨了这些差异，并提出了可能克服当前挑战的新模型的想法。