Recent advances in functional mesoporous silica-based nanoplatforms for combinational photo-chemotherapy of cancer.,Biomaterials

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Recent advances in functional mesoporous silica-based nanoplatforms for combinational photo-chemotherapy of cancer.
Biomaterials ( IF 12.8 ) Pub Date : 2019-12-27 , DOI: 10.1016/j.biomaterials.2019.119738
Yin-Jia Cheng ₁ , Jing-Jing Hu ₂ , Si-Yong Qin ₁ , Ai-Qing Zhang ₁ , Xian-Zheng Zhang ₂

Affiliation

In recent years, research trend has gradually removed from a concentration on monotherapy to combination therapy for fighting cancer. Combination photo-chemotherapy, including photodynamic-chemotherapy, photothermal-chemotherapy, as well as photodynamic-photothermal-chemotherapy, has demonstrated the priorities to elevate cancer therapeutic efficacies and diminish undesired side effects through different mechanisms in cancer treatment. In this review, we summarize the most recent progress in designing mesoporous silica-based nanoplatforms for combination delivery of multiple therapeutic agents, and discuss the treatment outcome in cancer by combining photodynamic therapy (PDT) and/or photothermal therapy (PTT) with chemotherapy. Furthermore, we highlight the drawbacks and challenges of employing mesoporous silica-based combinational formulations for effective cancer photo-chemotherapy, which might provide new guidelines for development of photo-chemo combination cancer treatments.

中文翻译：

功能性介孔二氧化硅基纳米平台用于癌症联合光化学疗法的最新进展。

近年来，研究趋势逐渐从集中于单一疗法转移到针对癌症的联合疗法。组合的光化学疗法，包括光动力化学疗法，光热化学疗法以及光动力光化学疗法，已经证明了通过不同的癌症治疗机制来提高癌症治疗效率和减少不良副作用的优先考虑。在这篇综述中，我们总结了设计中孔二氧化硅基纳米平台用于多种治疗药物联合递送的最新进展，并讨论了将光动力疗法（PDT）和/或光热疗法（PTT）与化学疗法相结合的癌症治疗结果。此外，

更新日期：2019-12-27

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