BACKGROUND Metachronous renal cell carcinoma after radical nephrectomy is extremely rare. Renal cell carcinoma commonly metastasizes to distant organs. However, metastasis to the urinary bladder is very uncommon. CASE PRESENTATION Herein, we report a case of metachronous renal cell carcinoma with metastasis to the urinary bladder, left acetabulum, left rib, lungs, thyroid, right renal vein and inferior vena cava. The patient had undergone a left-sided radical nephrectomy 28 years ago. The pathological diagnosis of a fragment of the bladder tumor was consistent with Fuhrman grade 2 clear cell renal cell carcinoma. CONCLUSIONS Although metachronous renal cell carcinoma after radical nephrectomy is rare, active surveillance should be still considered. Renal cell carcinoma has shown to unusually metastasize to the urinary bladder, a rarely reported organ of metastasis. Treatment options, such as immunotherapy, are available to patients with such metastasis and long-term survivorship can be achieved.

中文翻译：

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肾癌根治术后28年转移至膀胱和远处器官的异时肾细胞癌：1例病例报告。

背景技术根治性肾切除术后异时性肾细胞癌极为罕见。肾细胞癌通常转移到远处的器官。然而，转移至膀胱非常罕见。病例介绍在此，我们报道了一例转移至膀胱，左髋臼，左肋骨，肺，甲状腺，右肾静脉和下腔静脉的转移性肾细胞癌病例。该患者在28年前接受了左侧根治性肾切除术。膀胱肿瘤片段的病理诊断与Fuhrman 2级透明细胞肾细胞癌一致。结论尽管根治性肾切除术后异时性肾细胞癌很少见，但仍应考虑积极监测。肾细胞癌已显示出异常转移至膀胱，很少报道的转移器官。具有这种转移的患者可以使用诸如免疫疗法等治疗选择，并且可以实现长期生存。