BACKGROUND Genetic susceptibility to the development of coronary artery disease (CAD) and myocardial infarction (MI) is well established. However, lack of replication, and difficulty in the identification of specific genes that underlie impressive linkage peaks remain challenges at the molecular level due to the heterogeneity of phenotype and their associated genotypes. We present two cases of first-degree family members of acute myocardial infarction (AMI) having similar clinical and angiographic features of obstructive coronary lesions at same anatomic locations. CASE PRESENTATION The father presented with significant chest discomfort and loss of consciousness. The electrocardiogram (ECG) showed an acute anterior ST-segment-elevation myocardial infarction (STEMI). Coronary angiogram demonstrated a subtotal occlusion in the mid-left anterior descending (LAD) coronary artery. One week later, the son presented after an in-hospital cardiac arrest with pulseless electric activity preceded by significant chest pain and loss of consciousness. His ECG also showed an acute anterior STEMI. Catheterization revealed strikingly similar angiographic characteristics with his father: subtotal occlusion in the proximal to mid-LAD coronary artery. CONCLUSIONS More considerations should be given to patients with similar phenotypic characterization in genetic studies of CAD/MI in the future.

中文翻译：

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具有急性心肌梗死表型特征相似的一级亲属：一例病例报告并文献复习。

背景技术对冠状动脉疾病（CAD）和心肌梗塞（MI）的发展的遗传易感性已被很好地建立。然而，由于表型及其相关基因型的异质性，缺乏复制以及难以识别构成令人印象深刻的连锁峰的特定基因仍然是分子水平的挑战。我们介绍了两例急性心肌梗死（AMI）一级家庭成员，它们在相同的解剖位置具有相似的梗阻性冠状动脉病变的临床和血管造影特征。病例介绍父亲表现出明显的胸部不适和意识丧失。心电图（ECG）显示急性前ST段抬高型心肌梗塞（STEMI）。冠状动脉造影显示左中前降支（LAD）冠状动脉小计阻塞。一周后，儿子因无脉冲电活动的院内心脏骤停后出现明显的胸痛和意识丧失而出现。他的心电图还显示出急性前部STEMI。导管插入术显示出与他父亲非常相似的血管造影特征：LAD冠状动脉近端至中段的次全阻塞。结论将来在CAD / MI的基因研究中应更多考虑具有相似表型特征的患者。导管插入术显示出与他父亲非常相似的血管造影特征：LAD冠状动脉近端至中段的次全阻塞。结论将来在CAD / MI的基因研究中应更多考虑具有相似表型特征的患者。导管插入术显示出与他父亲非常相似的血管造影特征：LAD冠状动脉近端至中段的次全阻塞。结论将来在CAD / MI的基因研究中应更多考虑具有相似表型特征的患者。