A Society of Environmental Toxicology and Chemistry technical workshop was held in December 2017 to critically evaluate the current state of the science of metal bioavailability modeling. The availability of mechanistic models such as the biotic ligand model and the rapid development of empirical models such as multiple linear regressions means that choices are available in terms of bioavailability normalization approaches that can be used in metal risk assessments and the development of risk-based protective values for aquatic life. A key goal of the workshop was to provide potential users of metal bioavailability models with the information required to make appropriate decisions when choosing among mechanistic and empirical models. Workshop participants focused on the state of the science of metal bioavailability modeling, mechanistic and empirical model frameworks, validation of bioavailability models, and application of bioavailability models in risk-based decision-making approaches. The output of this workshop provides the necessary scientific information to incorporate bioavailability normalization in regulations pertaining to metals in freshwater systems. Environ Toxicol Chem 2019;39:42-47. © 2019 SETAC.

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金属生物利用度建模的科学现状：环境毒理学和化学学会技术研讨会成果简介。

环境毒理学和化学学会技术研讨会于 2017 年 12 月举行，以批判性地评估金属生物利用度建模科学的现状。机械模型（例如生物配体模型）的可用性和经验模型（例如多元线性回归）的快速发展意味着可以在生物利用度标准化方法方面进行选择，这些方法可用于金属风险评估和基于风险的保护性开发水生生物的价值。研讨会的一个关键目标是为金属生物利用度模型的潜在用户提供在机械模型和经验模型之间进行选择时做出适当决策所需的信息。研讨会参与者专注于金属生物利用度建模的科学现状，机制和经验模型框架，生物利用度模型的验证，以及生物利用度模型在基于风险的决策方法中的应用。该研讨会的成果提供了必要的科学信息，以将生物利用度标准化纳入与淡水系统中的金属有关的法规中。环境毒物化学 2019；39:42-47。© 2019 SETAC。