Template‐engineered metal macrocyclic complexes: Synthesis and biological activity,Journal of the Chinese Chemical Society

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Template‐engineered metal macrocyclic complexes: Synthesis and biological activity
Journal of the Chinese Chemical Society ( IF 1.6 ) Pub Date : 2019-12-27 , DOI: 10.1002/jccs.201900290
Vikas Sangwan ₁ , Dharam Pal Singh ₁

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Three new azamacrocylic complexes of divalent transition‐metal ions were synthesized by taking Co(II), Ni(II), and Cu(II) metal ions as templates. The macrocyclic ligand (1²Z ,5²Z ,5⁴E )‐1¹,1²,1³,1⁴,1⁵,1⁶,5¹,5²,5³,5⁴,5⁵,5⁶‐dodecahydro‐2,4,6,8‐tetraaza‐1 (2,4),5(4,2)‐pyrimidine‐3,7(1,2)‐dibenzenacyclooctaphane‐1⁶,5⁶‐dione was derived from o ‐phenylenediamine (OPD) and 2‐thiobarbituric acid (TBA). All the complexes were fully characterized through spectroscopic techniques and elemental analyses. The structures of the macrocyclic complexes were determined by IR, UV–vis, ESI‐MS, TGA, molar conductance, magnetic moment, and electron spin resonance data. On the basis of the above studies, the complexes may be formulated as [MLX₂], in which L is a macrocyclic ligand and X = CH₃COO⁻. All the macrocyclic complexes were biologically screened to evaluate their antimicrobial efficacy. DNA binding study of two representative complexes was performed by UV–vis titrations.

中文翻译：

模板工程化的金属大环配合物：合成与生物活性

以Co（II），Ni（II）和Cu（II）金属离子为模板合成了三价二价过渡金属离子的新的氮杂金属配合物。大环配位体（1个²Ž，5 ²Ž，5 ⁴ë）-1- ¹，1 ²，1 ³，1 ⁴，1 ⁵，1 ⁶，5 ¹，5 ²，5 ³，5 ⁴，5 ⁵， 5 ⁶ -dodecahydro -2,4,6,8-四氮杂- 1（2,4），5（4,2） -嘧啶-3,7-（1,2）-dibenzenacyclooctaphane-1 ⁶，5 ⁶ -二酮源自o苯二胺（OPD）和2-硫代巴比妥酸（TBA）。所有配合物均已通过光谱技术和元素分析得到了充分表征。大环配合物的结构由IR，UV-vis，ESI-MS，TGA，摩尔电导，磁矩和电子自旋共振数据确定。上述研究的基础上，该复合物可被配制为[MLX ₂ ]，其中L是大环配位且X = CH ₃ COO ^-。所有大环复合物都经过生物学筛选，以评估其抗菌功效。通过UV-vis滴定法进行了两种代表性复合物的DNA结合研究。

更新日期：2019-12-27

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