Molecular Connections Between Circadian Clocks and Aging.,Journal of Molecular Biology

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Molecular Connections Between Circadian Clocks and Aging.
Journal of Molecular Biology ( IF 4.7 ) Pub Date : 2019-12-27 , DOI: 10.1016/j.jmb.2019.12.036
Patrick-Simon Welz ₁ , S A Benitah ₂

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The mammalian circadian clockwork has evolved as a timing system that allows the daily environmental changes to be anticipated so that behavior and tissue physiology can be adjusted accordingly. The circadian clock synchronizes the function of all cells within tissues in order to temporally separate preclusive and potentially harmful physiologic processes and to establish a coherent temporal organismal physiology. Thus, the proper functioning of the circadian clockwork is essential for maintaining cellular and tissue homeostasis. Importantly, aging reduces the robustness of the circadian clock, resulting in disturbed sleep-wake cycles, a lowered capacity to synchronize circadian rhythms in peripheral tissues, and reprogramming of the circadian clock output at the molecular function levels. These circadian clock-dependent behavioral and molecular changes in turn further accelerate the process of aging. Here we review the current knowledge about how aging affects the circadian clock, how the functional decline of the circadian clock affects aging, and how the circadian clock machinery and the molecular processes that underlie aging are intertwined.

中文翻译：

昼夜节律与衰老之间的分子联系。

哺乳动物的生物钟已发展成为一种计时系统，可以预测每天的环境变化，从而可以相应地调节行为和组织生理。昼夜节律时钟同步组织内所有细胞的功能，以便暂时分离主要的和潜在有害的生理过程，并建立连贯的时间生物生理。因此，生物钟的正常运转对于维持细胞和组织的动态平衡至关重要。重要的是，老化降低了生物钟的健壮性，导致睡眠-觉醒周期受到干扰，降低了外周组织中生物钟的同步性的能力，以及在分子功能水平上对生物钟输出的重新编程。这些昼夜节律依赖的行为和分子变化进而进一步加速了衰老过程。在这里，我们回顾了有关衰老如何影响生物钟，生物钟功能下降如何影响衰老以及生物钟机制与衰老基础的分子过程如何相互交织的当前知识。

更新日期：2019-12-27

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