Highly Porous, Biocompatible Tough Hydrogels, Processable via Gel Fiber Spinning and 3D Gel Printing,Advanced Materials Interfaces

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Highly Porous, Biocompatible Tough Hydrogels, Processable via Gel Fiber Spinning and 3D Gel Printing
Advanced Materials Interfaces ( IF 4.3 ) Pub Date : 2019-12-27 , DOI: 10.1002/admi.201901770
Sina Naficy ₁ , Thi Yen Loan Le ₁ , Farshad Oveissi ₁ , Aeryne Lee _{1,

2,

3} , Jui Chien Hung _{4,

5} , Steven G. Wise _{4,

5} , David S. Winlaw _{2,

3} , Fariba Dehghani ₁

Affiliation

Conventional tough hydrogels offer enhanced mechanical properties and high toughness. Their application scope however is limited by their lack of processability. Here, a new porous tough hydrogel system is introduced which is processable via gel fiber spinning and 3D printing. The tough hydrogels are produced by rehydrating processable organogels developed by induced phase separation between two linear polymer chains capable of intermolecular hydrogen bonding. Through a slow sol–gel phase separation, highly porous gel networks made of hydrogen bonded polymer chains is formed. These organogels can be easily transformed to 3D printed multimaterial constructs or gel fibers, and after rehydration produce highly robust hydrogel structures. Although such hydrogels are highly porous and contain large amount of water, their strength can reach as high as 2000 kPa, with high elongation at break (≈900%), and tunable moduli ranging from 250 to 2000 kPa. The hydrogels have fracture energies larger than cartilage and demonstrate excellent load recovery because of their renewable hydrogen bond crosslinks. Furthermore, the hydrogels exhibit excellent hemocompatibility and in vitro biocompatibility. Such hydrogels can further expand the application of tough hydrogels and may serve as a model to explore the toughening mechanism of hydrogen bonded hybrid, tough hydrogel systems.

中文翻译：

具有高度多孔性，生物相容性的坚韧水凝胶，可通过凝胶纤维纺丝和3D凝胶印刷进行加工

常规的韧性水凝胶可提供增强的机械性能和高韧性。然而，它们的应用范围由于缺乏可加工性而受到限制。在这里，介绍了一种新的多孔坚韧水凝胶系统，该系统可通过凝胶纤维纺丝和3D打印进行处理。坚韧的水凝胶是通过将可分子间氢键合的两条线性聚合物链之间诱导相分离而形成的可水合有机凝胶再水化而生产的。通过缓慢的溶胶-凝胶相分离，形成了由氢键连接的聚合物链制成的高度多孔的凝胶网络。这些有机凝胶可轻松转化为3D打印的多材料构造或凝胶纤维，并且在再水化后可产生高度坚固的水凝胶结构。尽管此类水凝胶具有很高的多孔性并包含大量的水，它们的强度可高达2000 kPa，断裂伸长率高（≈900％），可调模量范围为250至2000 kPa。水凝胶具有比软骨更大的断裂能，并且由于其可再生的氢键交联而具有出色的负载恢复能力。此外，水凝胶显示出优异的血液相容性和体外生物相容性。这样的水凝胶可以进一步扩大硬水凝胶的应用范围，并且可以作为模型来探索氢键杂化硬水凝胶体系的增韧机理。水凝胶显示出极好的血液相容性和体外生物相容性。这样的水凝胶可以进一步扩大硬水凝胶的应用范围，并且可以作为模型来探索氢键杂化硬水凝胶体系的增韧机理。水凝胶显示出极好的血液相容性和体外生物相容性。这样的水凝胶可以进一步扩大硬水凝胶的应用范围，并且可以作为模型来探索氢键杂化硬水凝胶体系的增韧机理。

更新日期：2019-12-27

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