Three‐dimensional (3D) printing becomes an attractive technique to fabricate tissue engineering scaffolds through its high control on fabrication and repeatability using the printing parameters. This technique can be combined by the finite element method (FEM), and tissue‐specific scaffolds with desirable morphological and mechanical properties can be designed and manufactured. In this study, the influential 3D printing parameters on the morphological and mechanical properties of polycaprolactone (PCL) filament and scaffold were studied experimentally and numerically. First, the effects of printing parameters and process on the properties of extruded PCL filament were investigated. Then, using FEM, the effects of filament specifications on the overall characteristics of the scaffold were evaluated. Results showed that both the printing process in terms of resting time and remaining time and the printing parameters like pressure, printing speed, and printing path length have influenced the filament properties. In addition, both the filament diameter and elastic modulus had significant effects on the properties of scaffold especially, a 20% increase in the filament diameter caused the scaffold compressive elastic modulus to rise by around 72%. It is concluded that the printing parameters and process must be tuned very well in fabricating scaffolds with the desired morphology and mechanical property.

中文翻译：

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3D打印对聚己内酯长丝和支架的形态和力学性能的影响

三维（3D）打印通过对打印参数的高度控制以及对重复性的高度控制，成为制造组织工程支架的一种有吸引力的技术。该技术可以通过有限元方法（FEM）进行组合，并且可以设计和制造具有所需形态和机械性能的组织特异性支架。在这项研究中，通过实验和数值研究了3D打印参数对聚己内酯（PCL）细丝和支架的形态和机械性能的影响。首先，研究了印刷参数和工艺对挤出的PCL长丝性能的影响。然后，使用FEM，评估灯丝规格对支架整体特性的影响。结果表明，在静置时间和剩余时间方面的印刷过程以及诸如压力，印刷速度和印刷路径长度的印刷参数都影响了长丝的性能。此外，长丝直径和弹性模量都对支架的性能有显着影响，特别是，长丝直径增加20％会使支架的压缩弹性模量增加约72％。结论是，在制造具有所需形态和机械性能的脚手架时，必须很好地调整印刷参数和工艺。细丝直径和弹性模量都对支架的性能有显着影响，特别是，细丝直径增加20％会使支架的压缩弹性模量增加约72％。结论是，在制造具有所需形态和机械性能的脚手架时，必须很好地调整印刷参数和工艺。细丝直径和弹性模量都对支架的性能有显着影响，特别是，细丝直径增加20％会使支架的压缩弹性模量增加约72％。结论是，在制造具有所需形态和机械性能的脚手架时，必须很好地调整印刷参数和工艺。