Abdominal aortic aneurysm (AAA) is a serious, life‐threatening vascular disease that presents as an enlarged area of the aorta, which is the main artery that carries blood away from the heart. AAA may occur at any location in the aorta, but it is mainly found in the abdominal region. A ruptured AAA causes serious health issues, including death. Traditional imaging techniques, such as computed tomography angiogram, magnetic resonance imaging, and ultrasound sonography, have been used to identify AAAs. Circulating biomarkers have recently become attractive for diagnosing AAAs due to their cost‐effectiveness compared to imaging. Insulin‐like growth factor 1 (IGF‐1), a secreted hormone vital for human atherosclerotic plaque stability, has been found to be an efficient biomarker for AAA identification. In this report, immunosensing was performed by using an InterDigitated electrode (IDE) sensor to detect circulating levels of IGF‐1. The detection limit of IGF‐1 was found to be 100 fM with this sensor. Moreover, related protein controls (IGF‐2 and IGFBP3) were not detected with the same antibody, indicating selective IGF‐1 detection. Thus, immunosensing by using an IDE sensor may help to effectively diagnose AAAs and represents a basic platform for further development.

中文翻译：

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通过免疫感应高效检测腹主动脉瘤生物标志物。

腹主动脉瘤（AAA）是一种严重的，威胁生命的血管疾病，表现为主动脉的扩大区域，而主动脉是将血液带离心脏的主要动脉。AAA可能发生在主动脉的任何位置，但主要在腹部区域发现。AAA破裂会导致严重的健康问题，包括死亡。传统的成像技术，如计算机断层扫描血管造影，磁共振成像和超声检查，已被用于识别AAA。由于循环生物标志物与成像相比具有成本效益，因此最近对于诊断AAA变得有吸引力。胰岛素样生长因子1（IGF-1）是一种对人的动脉粥样硬化斑块稳定至关重要的分泌激素，已被发现是AAA鉴定的有效生物标志物。在这份报告中，免疫感应是通过使用间散电极（IDE）传感器进行的，以检测IGF-1的循环水平。使用该传感器发现IGF-1的检测极限为100 fM。此外，未使用同一抗体检测到相关的蛋白质对照（IGF-2和IGFBP3），表明选择性检测了IGF-1。因此，通过使用IDE传感器进行免疫感应可以帮助有效诊断AAA，并代表了进一步开发的基本平台。