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Quantitative T1 mapping indicates tumor infiltration beyond the enhancing part of glioblastomas.
NMR in Biomedicine ( IF 2.7 ) Pub Date : 2019-12-26 , DOI: 10.1002/nbm.4242 Ulrike Nöth 1 , Julia Tichy 2 , Stephanie Tritt 3 , Oliver Bähr 2 , Ralf Deichmann 1 , Elke Hattingen 3
NMR in Biomedicine ( IF 2.7 ) Pub Date : 2019-12-26 , DOI: 10.1002/nbm.4242 Ulrike Nöth 1 , Julia Tichy 2 , Stephanie Tritt 3 , Oliver Bähr 2 , Ralf Deichmann 1 , Elke Hattingen 3
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The aim of this study was to evaluate whether maps of quantitative T1 (qT1) differences induced by a gadolinium-based contrast agent (CA) are better suited than conventional T1-weighted (T1w) MR images for detecting infiltration inside and beyond the peritumoral edema of glioblastomas. Conventional T1w images and qT1 maps were obtained before and after gadolinium-based CA administration in 33 patients with glioblastoma before therapy. The following data were calculated: (i) absolute qT1-difference maps (qT1 pre-CA - qT1 post-CA), (ii) relative qT1-difference maps, (iii) absolute and (iv) relative differences of conventional T1w images acquired pre- and post-CA. The values of these four datasets were compared in four different regions: (a) the enhancing tumor, (b) the peritumoral edema, (c) a 5 mm zone around the pathology (defined as the sum of regions a and b), and (d) the contralateral normal appearing brain tissue. Additionally, absolute qT1-difference maps (displayed with linear gray scaling) were visually compared with respective conventional difference images. The enhancing tumor was visible both in the difference of conventional pre- and post-CA T1w images and in the absolute qT1-difference maps, whereas only the latter showed elevated values in the peritumoral edema and in some cases even beyond. Mean absolute qT1-difference values were significantly higher (P < 0.01) in the enhancing tumor (838 ± 210 ms), the peritumoral edema (123 ± 74 ms) and in the 5 mm zone around the pathology (81 ± 31 ms) than in normal appearing tissue (32 ± 35 ms). In summary, absolute qT1-difference maps-in contrast to the difference of T1w images-of untreated glioblastomas appear to be able to visualize CA leakage, and thus might indicate tumor cell infiltration in the edema region and beyond. Therefore, the absolute qT1-difference maps are potentially useful for treatment planning.
中文翻译：
定量的T1图谱表明胶质母细胞瘤的增强部分以外的肿瘤浸润。
这项研究的目的是评估由a基造影剂（CA）诱导的定量T1（qT1）差异图是否比常规T1加权（T1w）MR图像更适合检测肿瘤周围水肿内外的浸润胶质母细胞瘤。在治疗前，在33例胶质母细胞瘤患者中，以g为基础的CA给药前后，均获得了常规的T1w图像和qT1图。计算了以下数据：（i）绝对qT1差异图（qT1在CA前-qT1在CA之后），（ii）相对qT1差异图，（iii）采集的常规T1w图像的绝对和（iv）相对差异CA之前和之后。在四个不同区域对这四个数据集的值进行了比较：（a）肿瘤增强；（b）肿瘤周围水肿；（c）病理周围的5毫米区域（定义为区域a和b的总和），以及（d）对侧正常的脑组织。此外，在视觉上将绝对qT1差异图（以线性灰度显示）与相应的常规差异图像进行了比较。在常规CA T1w前后图像的差异以及绝对qT1差异图中均可见到增强的肿瘤，而只有后者显示出在肿瘤周围水肿中的升高值，在某些情况下甚至更高。在增强肿瘤（838±210 ms），肿瘤周围水肿（123±74 ms）和病理周围5 mm区域（81±31 ms）中，平均绝对qT1差值显着高于（P <0.01）。在正常出现的组织中（32±35 ms）。总之，未经处理的胶质母细胞瘤的绝对qT1差异图（与T1w图像的差异相反）似乎能够可视化CA渗漏，因此可能表明肿瘤细胞在水肿区域及其他区域浸润。因此，绝对的qT1差异图可能对治疗计划有用。
更新日期：2020-02-04
中文翻译：
定量的T1图谱表明胶质母细胞瘤的增强部分以外的肿瘤浸润。
这项研究的目的是评估由a基造影剂（CA）诱导的定量T1（qT1）差异图是否比常规T1加权（T1w）MR图像更适合检测肿瘤周围水肿内外的浸润胶质母细胞瘤。在治疗前，在33例胶质母细胞瘤患者中，以g为基础的CA给药前后，均获得了常规的T1w图像和qT1图。计算了以下数据：（i）绝对qT1差异图（qT1在CA前-qT1在CA之后），（ii）相对qT1差异图，（iii）采集的常规T1w图像的绝对和（iv）相对差异CA之前和之后。在四个不同区域对这四个数据集的值进行了比较：（a）肿瘤增强；（b）肿瘤周围水肿；（c）病理周围的5毫米区域（定义为区域a和b的总和），以及（d）对侧正常的脑组织。此外，在视觉上将绝对qT1差异图（以线性灰度显示）与相应的常规差异图像进行了比较。在常规CA T1w前后图像的差异以及绝对qT1差异图中均可见到增强的肿瘤，而只有后者显示出在肿瘤周围水肿中的升高值，在某些情况下甚至更高。在增强肿瘤（838±210 ms），肿瘤周围水肿（123±74 ms）和病理周围5 mm区域（81±31 ms）中，平均绝对qT1差值显着高于（P <0.01）。在正常出现的组织中（32±35 ms）。总之，未经处理的胶质母细胞瘤的绝对qT1差异图（与T1w图像的差异相反）似乎能够可视化CA渗漏，因此可能表明肿瘤细胞在水肿区域及其他区域浸润。因此，绝对的qT1差异图可能对治疗计划有用。
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