So far, there have been no analyses of correlations between the level of water-soluble vitamins in women with polycystic ovary syndrome (PCOS) and hormone and lipid profiles as well as carbohydrate metabolism. The unpopular concept that PCOS may also be conditioned by a chronic infection leads to a suspicion that water-soluble vitamins may be involved in the struggle against PCOS. This is why the aim of this research was to determine whether there are any indications that could confirm this hypothesis. The study included 64 women of Caucasian race: 50 patients aged 29.52 ± 7.01 years with PCOS, diagnosed according to the Rotterdam criteria. The control group consisted of 14 women aged 30.23 ± 6.3 years with correct BMI. HPLC Infinity1260 Binary LC (Agilent Technologies, Waldbronn, Germany) was used to analyze nine vitamins. The vitamins were separated using the gradient method, a buffer of 25 mM HK2PO4 with pH equal to 7.0, and 100 % methanol buffer. The acquired results were compared using Statistica 12.0 (Statsoft, Tulsa, Oklahoma, USA). Non-parametric tests were used: Mann-Whitney tests for comparisons between groups (PCOS and control group, CG), in which p < 0.05 was considered statistically significant. Subsequently, we performed a correlation matrix of the biochemical parameters of blood with vitamins at p ≤ 0.05. Higher concentrations of ascorbic acid were observed in PCOS. The content of the remaining vitamins was higher in the control group, and the statistical differences were significant in reference to thiamine, riboflavin, pyridoxine and folic acid in comparison to the control group. A significant positive correlation was observed between vitamin C and testosterone/insulin, another between riboflavin and androstenedione/testosterone, next between biotin and thyrotropic hormone (TSH), between pantothenic acid and dehydroepiandrosteron (DHEA-SO4), and finally between pyridoxine and androstenedione. A negative correlation was observed in the case of niacin with sex hormone binding protein (SHBG) and high density lipoprotein (HDL). Water-soluble vitamins play an important role in the therapy of women with PCOS through the reduction of antioxidative stress and low-intensity inflammation caused by various factors, including chronic infection.

中文翻译：

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血浆中维生素含量与PCOS中糖代谢参数以及激素和脂质谱的参数有关。

到目前为止，还没有分析多囊卵巢综合征（PCOS）妇女的水溶性维生素水平与激素和脂质谱以及碳水化合物代谢之间的相关性。PCOS也可能受到慢性感染的影响这一不受欢迎的概念导致人们怀疑水溶性维生素可能参与了抗PCOS的斗争。这就是为什么本研究旨在确定是否有任何迹象可以证实这一假设的原因。该研究包括64位白人，其中50位年龄29.52±7.01岁的PCOS患者是根据鹿特丹标准诊断的。对照组由14名年龄在30.23±6.3岁，BMI正确的女性组成。HPLC Infinity1260 Binary LC（Agilent Technologies，Waldbronn，德国）用于分析9种维生素。使用梯度方法，pH等于7.0的25 mM HK2PO4缓冲液和100％甲醇缓冲液分离维生素。使用Statistica 12.0（美国俄亥俄州俄克拉荷马州塔尔萨市的Statsofta）比较获得的结果。使用非参数检验：Mann-Whitney检验用于各组之间的比较（PCOS和对照组，CG），其中p <0.05被认为具有统计学意义。随后，我们对维生素与p≤0.05的血液的生化参数进行了相关矩阵分析。在PCOS中观察到较高的抗坏血酸浓度。对照组中剩余的维生素含量较高，与对照组相比，硫胺素，核黄素，吡ido醇和叶酸的统计差异显着。维生素C与睾丸激素/胰岛素之间存在显着正相关，核黄素与雄烯二酮/睾丸激素之间存在显着正相关，其次是生物素与促甲状腺激素（TSH）之间，泛酸与脱氢表雄酮（DHEA-SO4）之间，以及吡pyr醇与雄烯二酮之间存在显着正相关。烟酸与性激素结合蛋白（SHBG）和高密度脂蛋白（HDL）呈负相关。水溶性维生素通过减少由多种因素（包括慢性感染）引起的抗氧化应激和低强度炎症，在治疗PCOS妇女中起着重要作用。在泛酸和脱氢表雄酮（DHEA-SO4）之间，最后在吡ido醇和雄烯二酮之间。烟酸与性激素结合蛋白（SHBG）和高密度脂蛋白（HDL）呈负相关。水溶性维生素通过减少由多种因素（包括慢性感染）引起的抗氧化应激和低强度炎症，在治疗PCOS妇女中起着重要作用。在泛酸和脱氢表雄酮（DHEA-SO4）之间，最后在吡ido醇和雄烯二酮之间。烟酸与性激素结合蛋白（SHBG）和高密度脂蛋白（HDL）呈负相关。水溶性维生素通过减少由多种因素（包括慢性感染）引起的抗氧化应激和低强度炎症，在治疗PCOS妇女中起着重要作用。