Kinesin-6 KIF20A is essential for microtubule organization and central spindle assembly during cytokinesis. However, the functions of KIF20A in meiotic division and spermatogenesis remain elusive. Here, we report that kinesin-6 KIF20A locates at the microtubules in mouse spermatogenic cells and co-localizes with the spindle midzone and midbody. We demonstrate that central spindle organization and chromosomal stability are regulated by KIF20A in male meiotic division. KIF20A inhibition leads to the defects in central spindle assembly and cytokinetic abscission, and finally results in the increase of aneuploid cells and the alteration of cell populations in the spermatogenic cells. Furthermore, we have revealed that kinesin-6 KIF20A is associated with the formation and maturation of the acrosomes during spermatogenesis. Our findings have identified the specific roles of KIF20A in central spindle organization in meiotic division.

中文翻译：

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Kinesin-6家族运动KIF20A调节小鼠精子发生过程中的中心纺锤体组装和顶体生物发生。

Kinesin-6 KIF20A对于胞质分裂过程中的微管组织和中心纺锤体组装至关重要。然而，KIF20A在减数分裂和精子发生中的功能仍然难以捉摸。在这里，我们报告驱动蛋白6 KIF20A位于小鼠生精细胞中的微管，并与纺锤体中区和中体共定位。我们证明，在男性减数分裂分裂中，KIF20A调控着中心纺锤体的组织和染色体的稳定性。KIF20A抑制导致中心纺锤体组装和细胞动力学脱落的缺陷，并最终导致非整倍体细胞的增加和生精细胞中细胞群的改变。此外，我们发现驱动蛋白6 KIF20A与精子发生过程中顶体的形成和成熟有关。