当前位置：
X-MOL 学术
›
Cell Stem Cell
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Endometrial Axin2+ Cells Drive Epithelial Homeostasis, Regeneration, and Cancer following Oncogenic Transformation.
Cell Stem Cell ( IF 19.8 ) Pub Date : 2019-12-26 , DOI: 10.1016/j.stem.2019.11.012 Shafiq M Syed 1 , Manish Kumar 1 , Arnab Ghosh 1 , Florence Tomasetig 2 , Ayesha Ali 1 , Renee M Whan 2 , Dariusz Alterman 3 , Pradeep S Tanwar 1
Cell Stem Cell ( IF 19.8 ) Pub Date : 2019-12-26 , DOI: 10.1016/j.stem.2019.11.012 Shafiq M Syed 1 , Manish Kumar 1 , Arnab Ghosh 1 , Florence Tomasetig 2 , Ayesha Ali 1 , Renee M Whan 2 , Dariusz Alterman 3 , Pradeep S Tanwar 1
Affiliation
|
The remarkable regenerative capacity of the endometrium (the inner lining of the uterus) is essential for the sustenance of mammalian life. Over the years, the role of stem cells in endometrial functions and their pathologies has been suggested; however, the identity and location of such stem cells remain unclear. Here, we used in vivo lineage tracing to show that endometrial epithelium self-renews during development, growth, and regeneration and identified Axin2, a classical Wnt reporter gene, as a marker of long-lived bipotent epithelial progenitors that reside in endometrial glands. Axin2-expressing cells are responsible for epithelial regeneration in vivo and for endometrial organoid development in vitro. Ablation of Axin2+ cells severely impairs endometrial homeostasis and compromises its regeneration. More important, upon oncogenic transformation, these cells can lead to endometrial cancer. These findings provide valuable insights into the cellular basis of endometrial functions and diseases.
中文翻译：
子宫内膜Axin2 +细胞在致癌性转化后驱动上皮稳态，再生和癌症。
子宫内膜（子宫内层）的显着再生能力对于维持哺乳动物生命至关重要。多年来，已经提出了干细胞在子宫内膜功能及其病理中的作用。然而，这种干细胞的身份和位置仍不清楚。在这里，我们使用体内谱系追踪显示子宫内膜上皮在发育，生长和再生过程中自我更新，并将经典的Wnt报告基因Axin2鉴定为驻留在子宫内膜腺体中的长寿双能上皮祖细胞的标志物。表达Axin2的细胞负责体内上皮再生，并负责体外子宫内膜类器官的发育。Axin2 +细胞的消融严重损害子宫内膜稳态并损害其再生。更重要，在致癌性转化后，这些细胞可导致子宫内膜癌。这些发现为子宫内膜功能和疾病的细胞基础提供了有价值的见解。
更新日期：2019-12-27
中文翻译：
子宫内膜Axin2 +细胞在致癌性转化后驱动上皮稳态，再生和癌症。
子宫内膜（子宫内层）的显着再生能力对于维持哺乳动物生命至关重要。多年来，已经提出了干细胞在子宫内膜功能及其病理中的作用。然而，这种干细胞的身份和位置仍不清楚。在这里，我们使用体内谱系追踪显示子宫内膜上皮在发育，生长和再生过程中自我更新，并将经典的Wnt报告基因Axin2鉴定为驻留在子宫内膜腺体中的长寿双能上皮祖细胞的标志物。表达Axin2的细胞负责体内上皮再生，并负责体外子宫内膜类器官的发育。Axin2 +细胞的消融严重损害子宫内膜稳态并损害其再生。更重要，在致癌性转化后，这些细胞可导致子宫内膜癌。这些发现为子宫内膜功能和疾病的细胞基础提供了有价值的见解。
京公网安备 11010802027423号