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Synthesis and cytotoxic evaluation of halogenated α-exo-methylene-lactones.
Bioorganic & Medicinal Chemistry ( IF 3.3 ) Pub Date : 2019-12-26 , DOI: 10.1016/j.bmc.2019.115281 Haoquan He 1 , Zheng Liu 2 , Wei Wang 1 , Xiaojian Jiang 1
Bioorganic & Medicinal Chemistry ( IF 3.3 ) Pub Date : 2019-12-26 , DOI: 10.1016/j.bmc.2019.115281 Haoquan He 1 , Zheng Liu 2 , Wei Wang 1 , Xiaojian Jiang 1
Affiliation
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α-exo-Methylene-γ-butyrolactones and α-exo-methylene-δ-valerolactones constitute an important group of natural and bioactive products. A simple and general protocol of halolactonization of dienoic acids to obtain various α-exo-methylene-lactones in excellent yields is described. The resulting halogenated α-exo-methylene-lactones were found to exhibit potent cytotoxic activities.
中文翻译：
卤代α-exo-亚甲基内酯的合成及细胞毒性评估。
α-exo-亚甲基-γ-丁内酯和α-exo-亚甲基-δ-戊内酯构成了重要的天然和生物活性产物组。描述了一种简单且通用的将己二酸卤代内酯化以优良收率获得各种α-exo-亚甲基-内酯的方案。发现所得的卤化的α-外-亚甲基-内酯表现出有效的细胞毒性活性。
更新日期：2019-12-27
中文翻译：
卤代α-exo-亚甲基内酯的合成及细胞毒性评估。
α-exo-亚甲基-γ-丁内酯和α-exo-亚甲基-δ-戊内酯构成了重要的天然和生物活性产物组。描述了一种简单且通用的将己二酸卤代内酯化以优良收率获得各种α-exo-亚甲基-内酯的方案。发现所得的卤化的α-外-亚甲基-内酯表现出有效的细胞毒性活性。
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