Alzheimer Disease (AD) is the main cause of dementia, and it has a great social and economic impact worldwide. It is a complex multifactorial disease, and we still do not know enough about its causes. For this reason, omics studies could be a useful tool for the search for new biomarkers and for enhancing the knowledge of different metabolic pathways that may be altered in the initial stages of the disease. Metabolomic analysis was carried out for plasma samples from early AD patients and healthy controls. Obtained data were normalized and analyzed by volcano plot and supervised orthogonal-least-squares-discriminant analysis. Fifteen variables were selected as the most important variables for the groups' discrimination, and the different levels of 6 identified metabolites could discriminate between patients with different ApoE4 genotypes (ε4-carriers and non ε4-carriers). In conclusion, ApoE4 genotype is associated with changes in lipid metabolomics profile in AD patients, and it could be relevant for the development of AD since early stages.

中文翻译：

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代谢组学研究，以识别老年痴呆症中的血浆生物标志物：ApoE基因型效应。

阿尔茨海默氏病（AD）是痴呆症的主要原因，在全世界范围内都具有巨大的社会和经济影响。它是一种复杂的多因素疾病，我们对其病因仍知之甚少。因此，组学研究可能是寻找新的生物标志物和增强对在疾病初始阶段可能改变的不同代谢途径的了解的有用工具。对来自早期AD患者和健康对照的血浆样品进行了代谢组学分析。通过火山图和监督的正交最小二乘判别分析对获得的数据进行归一化和分析。选择了15个变量作为对这些群体进行歧视的最重要变量，并且可以区分具有不同ApoE4基因型（ε4携带者和非ε4携带者）的6种代谢产物。总之，ApoE4基因型与AD患者脂质代谢组学谱的变化有关，并且自早期起就可能与AD的发展有关。