Little is known about the impact of family history of psychosis on youth from community samples. To fill this gap, we compared youth with a first-degree relative with psychosis spectrum symptoms (i.e. family history of psychosis spectrum symptoms, FHPS) to youth without FHPS in a cross-sectional analysis of the Philadelphia Neurodevelopmental Cohort (PNC). The PNC is a racially diverse community sample of 9498 youth ages 8-21 years old, of whom 8928 completed the Family Interview for Genetic Studies to determine FHPS status. Polygenic risk score for schizophrenia (PRSS) was available for a subsample of 4433 European Americans. FHPS youth (n = 489) constituted 5.5% of the analytic sample. After adjusting for environmental risk factors (sociodemographic variables and traumatic stressful events), FHPS youth had lower functioning on the Children's Global Assessment Scale and elevated psychosis spectrum, mood, externalizing, and fear symptoms compared to non-FHPS youth (all p < .001). In the European-American subsample, FHPS status was associated with poorer functioning and greater symptom burden in all four psychopathology domains (all p < .001), even after covarying for PRSS. Thus, ascertaining FHPS is important because it is uniquely associated with symptoms and functional impairment in community youth beyond PRS-S and the environmental risk factors we investigated. Future research identifying environmental causes of FHPS-associated impairment could inform the development of interventions for the broad array of symptoms observed in FHPS youth.

中文翻译：

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费城神经发育队列中报告有精神病谱系症状家族史的青少年的特征

从社区样本来看，人们对精神病家族史对青少年的影响知之甚少。为了填补这一空白，我们在费城神经发育队列 (PNC) 的横断面分析中，将一级亲属患有精神病谱系症状（即精神病谱系症状家族史，FHPS）的青少年与没有 FHPS 的青少年进行了比较。PNC 是一个由 9498 名 8-21 岁青少年组成的种族多元化社区样本，其中 8928 人完成了基因研究家庭访谈以确定 FHPS 状态。精神分裂症多基因风险评分 (PRSS) 适用于 4433 名欧洲裔美国人的子样本。FHPS 青年 (n = 489) 占分析样本的 5.5%。在调整环境风险因素（社会人口统计学变量和创伤性应激事件）后，与非 FHPS 青少年相比，FHPS 青少年在儿童整体评估量表中的功能较低，精神病谱系、情绪、外化和恐惧症状较高（所有 p < .001） ）。在欧美子样本中，FHPS 状态与所有四个精神病理学领域的较差功能和较大症状负担相关（所有 p < .001），即使在 PRSS 共变之后也是如此。因此，确定 FHPS 很重要，因为除了 PRS-S 和我们调查的环境风险因素之外，它与社区青少年的症状和功能障碍具有独特的相关性。未来的研究确定 FHPS 相关损伤的环境原因可以为针对 FHPS 青少年中观察到的广泛症状制定干预措施提供信息。