Tandem heterocyclization of 2‐(azolyl‐(azinyl‐))anilines as an efficient method for preparation of substituted pyrrolo[1,2‐a]azolo‐(azino‐)[c]quinazolines,Journal of Heterocyclic Chemistry

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Tandem heterocyclization of 2‐(azolyl‐(azinyl‐))anilines as an efficient method for preparation of substituted pyrrolo[1,2‐a]azolo‐(azino‐)[c]quinazolines
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2019-12-25 , DOI: 10.1002/jhet.3862
Viktor Stavytskyi ₁ , Oleksii Voskoboinik ₁ , Oleksii Antypenko ₁ , Nataliia Krasovska ₁ , Konstantyn Shabelnyk ₁ , Iryna Konovalova ₂ , Svitlana Shishkyna ₂ , Sergiy Kholodniak ₁ , Serhii Kovalenko ₁

Affiliation

The synthesis of novel pyrrolo[1,2‐a]azolo‐(azino‐)[c]quinazolines by tandem reaction of 2‐(azolyl‐(azinyl‐))anilines with oxocarboxylic acids was described in this article. The mechanism of obtained compounds formation was proposed, and the intermediate of the heterocyclization has been isolated and characterized. The IR‐, ¹H and ¹³C NMR‐, chromato‐mass spectra of synthesized compounds were studied for estimation of their structure and spectral patterns features. The molecular structure of the obtained compounds was additionally proved by X‐ray diffraction method.

中文翻译：

2-（偶氮基-（叠氮基-））苯胺的串联杂环化是制备取代吡咯并[1,2-a] azolo-（叠氮基] [c]喹唑啉的有效方法

新颖吡咯并[1,2的合成一个[ - ] azolo-（连氮基）ç ]喹唑啉通过2-串联反应（azolyl-（吖嗪基- ））与氧代羧酸苯胺本文中被描述。提出了形成化合物的机理，并对杂环化的中间体进行了分离和表征。研究了合成化合物的IR，¹ H和¹³ C NMR，色谱质谱，以评估其结构和光谱图特征。所得化合物的分子结构还通过X射线衍射法证明。

更新日期：2019-12-27

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