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Insights into biomonitoring of human exposure to polycyclic aromatic hydrocarbons with hair analysis: A case study in e-waste recycling area.
Environment International ( IF 10.3 ) Pub Date : 2019-12-26 , DOI: 10.1016/j.envint.2019.105432
Meiqing Lin 1 , Jian Tang 2 , Shengtao Ma 3 , Yingxin Yu 2 , Guiying Li 2 , Ruifang Fan 4 , Bixian Mai 5 , Taicheng An 2
Affiliation  

In this study, 96 pairs of hair and urine samples were collected from e-waste (EW) dismantling workers of an industrial park, as well as residents living in surrounding areas. The concentrations of polycyclic aromatic hydrocarbons (PAHs) and hydroxylated PAH metabolites (OH-PAHs) were analyzed . The results show that concentrations of Σ15PAHs ranged from 6.24 to 692 ng/g dry weight (dw) and Σ12OH-PAHs from undetected to 187 ng/g dw in hair external (hair-Ex), and ranged from 31.7 to 738 ng/g dw and 21.6 to 1887 ng/g dw in hair internal (hair-In). There was no significant difference in exposure levels between EW dismantling workers and residents of the surrounding area. For the parent PAHs, the concentrations of Σ15PAHs of hair-In were comparable with those of hair-Ex for all populations except for the child residents. On the contrary, for the OH-PAHs, the concentrations of Σ12OH-PAHs of hair-In were 9-37 times higher than those of hair-Ex for populations. Moreover, the congener profiles of OH-PAHs of hair-In were different from those of hair-Ex, but similar to that of urine. Particularly, 3-OH-Bap, which is a carcinogenic metabolite, was only detected in the hair-In. These results indicate that OH-PAHs in hair-In, just like in urine, are mainly derived from endogenous metabolism and could be considered as reliable biomarkers for PAHs exposure. However, there was almost no significant correlations between hair-In and urine for OH-PAHs. This indicates that more attention should be paid to OH-PAHs when conducting PAHs exposure risk assessment using hair, which will help to obtain more reliable and comprehensive information on health risk assessments.

中文翻译:

用头发分析技术对人类暴露于多环芳烃的生物监测的见解:电子废物回收领域的案例研究。

在这项研究中,从一个工业园区的电子废物(EW)拆卸工人以及周围居民中收集了96对头发和尿液样本。分析了多环芳烃(PAHs)和羟基化PAH代谢物(OH-PAHs)的浓度。结果表明,在头发外部(hair-Ex)中,未检测到的Σ15PAHs浓度范围为6.24至692 ng / g干重(dw),而未检测到的Σ12OH-PAHs浓度为187 ng / g dw,范围为31.7至738 ng / g。 dw和头发内部(hair-In)的21.6至1887 ng / g dw。电子战拆解工人与周围地区居民之间的暴露水平没有显着差异。对于亲代PAHs,除了儿童居民外,所有人群的hair-In的Σ15PAHs浓度均与hair-Ex的浓度相当。相反,对于OH-PAHs,对于人群来说,hair-In的Σ12OH-PAHs浓度是hair-Ex的9-37倍。此外,hair-In的OH-PAHs的同类物谱与hair-Ex的同类,但与尿液相似。特别是,仅在发夹中检测到了致癌代谢物3-OH-Bap。这些结果表明,头发中的OH-PAHs与尿液中的OH-PAHs主要来自内源性代谢,可以被认为是PAHs暴露的可靠生物标志物。但是,OH-PAHs的头发和尿液之间几乎没有显着的相关性。这表明在使用毛发进行PAHs暴露风险评估时,应更加关注OH-PAH,这将有助于获得有关健康风险评估的更可靠,更全面的信息。人群中,hair-In的Σ12OH-PAHs浓度是hair-Ex的9-37倍。此外,hair-In的OH-PAHs的同类物谱与hair-Ex的同类,但与尿液相似。特别是,仅在发夹中检测到了致癌代谢物3-OH-Bap。这些结果表明,头发中的OH-PAHs与尿液中的OH-PAHs主要来自内源性代谢,可以被认为是PAHs暴露的可靠生物标志物。但是,OH-PAHs的头发和尿液之间几乎没有显着的相关性。这表明在使用毛发进行PAHs暴露风险评估时,应更加关注OH-PAH,这将有助于获得有关健康风险评估的更可靠,更全面的信息。人群中,hair-In的Σ12OH-PAHs浓度是hair-Ex的9-37倍。此外,hair-In的OH-PAHs的同类物谱与hair-Ex的同类,但与尿液相似。特别是,仅在发夹中检测到了致癌代谢物3-OH-Bap。这些结果表明,头发中的OH-PAHs与尿液中的OH-PAHs主要来自内源性代谢,可以被认为是PAHs暴露的可靠生物标志物。但是,OH-PAHs的头发和尿液之间几乎没有显着的相关性。这表明在使用毛发进行PAHs暴露风险评估时,应更加关注OH-PAH,这将有助于获得有关健康风险评估的更可靠,更全面的信息。
更新日期:2019-12-27
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