OBJECTIVES To conduct an updated systematic review and meta-analysis of association between sleep and all-cause cognitive disorders. METHODS PubMed and EMBASE were searched from inception to 18 February 2019. Cohort studies exploring longitudinal associations of sleep with cognitive decline or dementia were included. The multivariable-adjusted effect estimates were pooled by random-effects models, with credibility assessment. The robust error meta-regression model was used to conduct the dose-response meta-analysis for sleep duration. RESULTS 11 155 reports were searched and 51 eligible cohorts with 15 sleep problems were included for our meta-analyses. Ten types of sleep conditions or parameters, including six (insomnia, fragmentation, daytime dysfunction, prolonged latency, rapid eye movement sleep behaviour disorder and excessive time in bed) with moderate-to-high levels of evidence, were linked to higher risk of all-cause cognitive disorders. Furthermore, a U-shaped relationship was revealed for the associations with sleep duration. CONCLUSIONS Sleep management might serve as a promising target for dementia prevention.

中文翻译：

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睡眠问题和全因认知下降或痴呆的风险：最新的系统评价和荟萃分析。

目的对睡眠与全因认知障碍之间的关联进行更新的系统综述和荟萃分析。方法从开始到2019年2月18日，对PubMed和EMBASE进行搜索。队列研究探讨了睡眠与认知能力下降或痴呆的纵向关系。多变量调整后的效果评估通过随机效果模型进行汇总，并进行可信度评估。鲁棒误差元回归模型用于进行睡眠时间的剂量反应元分析。结果检索了11 155个报告，纳入了51个符合条件的队列研究，这些队列具有15个睡眠问题，用于我们的荟萃分析。十种睡眠状况或参数，包括六种（失眠，破碎，白天功能障碍，长时间潜伏，快速眼动睡眠行为障碍和卧床时间过长）以及中到高水平的证据与全因认知障碍的较高风险相关。此外，揭示了与睡眠时间相关的U形关系。结论睡眠管理可能是预防痴呆的有希望的目标。